{"id":"W2017888677","doi":"10.1016/j.devcel.2007.05.008","title":"A CUL-2 Ubiquitin Ligase Containing Three FEM Proteins Degrades TRA-1 to Regulate C. elegans Sex Determination","year":2007,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; American Cancer Society","keywords":"Biology; Caenorhabditis elegans; Ubiquitin ligase; Ubiquitin; Proteasome; Mutant; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004210519,0.0002576431,0.0001735652,0.00009099345,0.0001758362,0.00005808464,0.0002473767,0.000175269,0.00002556629],"category_scores_gemma":[0.00002969528,0.0002771485,0.00006886112,0.0001148494,0.00005308711,0.000007586603,0.0001384673,0.0001117931,0.00004850688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008126267,"about_ca_system_score_gemma":0.0001169187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003784637,"about_ca_topic_score_gemma":0.0009157961,"domain_scores_codex":[0.9984404,0.0000280117,0.0003410976,0.0004741524,0.000222126,0.0004941525],"domain_scores_gemma":[0.9994023,0.00001075482,0.00009129039,0.0002185655,0.00007022394,0.0002068205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007259883,0.00008835327,0.005967249,0.00003370314,0.00001901671,0.00002896211,0.002280776,0.00001690095,0.9771015,0.00001444773,0.000236819,0.01413966],"study_design_scores_gemma":[0.0005349767,0.0003209463,0.01633043,0.00002068365,0.00001317319,0.00004121664,0.0007443687,0.00004359923,0.9743219,0.00006415191,0.007164722,0.0003998378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550256,0.0001090206,0.0408694,0.00008921551,0.0001174852,0.0005339937,0.000009521026,0.00003676269,0.00320896],"genre_scores_gemma":[0.9617651,0.00001343538,0.03538244,0.0005987559,0.0001456408,0.00003197457,0.0001150766,0.00004734616,0.001900287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01373982,"threshold_uncertainty_score":0.9999681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266256606421862,"score_gpt":0.2345474949387754,"score_spread":0.2218849288745568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}