{"id":"W2017891964","doi":"10.2147/ndt.s62323","title":"Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative","year":2014,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; Janssen Research and Development; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Clinical Dementia Rating; Alzheimer's Disease Neuroimaging Initiative; Dementia; Disease; Internal medicine; Neuroimaging; Alzheimer's disease; Oncology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008292512,0.0017469,0.001815513,0.001581377,0.0007503483,0.001525097,0.002615368,0.001468896,0.00611863],"category_scores_gemma":[0.007839334,0.0008250535,0.002892928,0.0007769561,0.0006320438,0.001004377,0.001421418,0.003514343,0.001794748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002339575,"about_ca_system_score_gemma":0.002881507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03009353,"about_ca_topic_score_gemma":0.02244394,"domain_scores_codex":[0.998052,0.001045946,0.000061676,0.000477376,0.0001403217,0.0002228207],"domain_scores_gemma":[0.9953188,0.00316395,0.0005006999,0.0002251897,0.0006031981,0.0001880824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002391412,0.00066254,0.1889833,0.0002948976,0.001468773,0.0008644061,0.0007075331,0.7414513,0.001408049,0.01520427,0.0109694,0.03559409],"study_design_scores_gemma":[0.0002273842,0.0003359258,0.01523819,0.00004660646,0.0002693025,0.0002748286,0.00008471013,0.9741974,0.0001653927,0.005916017,0.003201217,0.00004302565],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7282363,0.001498736,0.2384948,0.003151962,0.0003316883,0.001418734,0.01982854,0.001115946,0.005923303],"genre_scores_gemma":[0.9262651,0.0005802593,0.03880164,0.0003318718,0.0001216777,0.002550053,0.01406179,0.0001730816,0.01711453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03009353,"threshold_uncertainty_score":0.05983669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0995722636197558,"score_gpt":0.3980843928982352,"score_spread":0.2985121292784794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}