{"id":"W2017893245","doi":"10.1016/j.intimp.2007.12.004","title":"Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms","year":2008,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Pharmacokinetics; Biodistribution; Antibody; Monoclonal antibody; Pharmacology; Volume of distribution; Bioavailability; Immunology; Neutralization; Chemistry; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008891292,0.0002367945,0.0004346136,0.0001391096,0.00012025,0.00001631716,0.0001686487,0.0001066139,0.000551904],"category_scores_gemma":[0.00005653688,0.0001858353,0.00009399724,0.00008247465,0.00054641,0.0001252969,0.0001207675,0.0002135746,0.000008503991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007356556,"about_ca_system_score_gemma":0.00007431173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000285129,"about_ca_topic_score_gemma":0.000004073732,"domain_scores_codex":[0.9984802,0.0001000113,0.0005358578,0.0003332715,0.0003329773,0.000217668],"domain_scores_gemma":[0.9989595,0.0001131335,0.0002599473,0.0001205944,0.0004296522,0.0001171638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004302253,0.001912307,0.09648895,0.0001623382,0.00118815,0.0003320353,0.0006297246,0.0002150412,0.8857022,0.001833667,0.002910154,0.004323191],"study_design_scores_gemma":[0.007572039,0.001197252,0.6563106,0.0001448899,0.0004196065,0.0003686032,0.0001508001,0.002006505,0.3235722,0.0001341232,0.007825021,0.0002983421],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933714,0.0007013419,0.00358276,0.0006999241,0.0008342974,0.0003776142,0.0002279702,0.00005972768,0.0001449397],"genre_scores_gemma":[0.996756,0.001577371,0.0001975904,0.000325706,0.0002506749,0.00002749826,0.0004467856,0.00002478662,0.0003936491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5621299,"threshold_uncertainty_score":0.7578144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481380980680441,"score_gpt":0.3319974615719588,"score_spread":0.3071836517651544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}