{"id":"W2017908039","doi":"10.1007/s00280-013-2176-z","title":"Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues","year":2013,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Topotecan; Mitoxantrone; Doxorubicin; Pharmacology; Medicine; Distribution (mathematics); Anticancer drug; Chemotherapy; Drug; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007527759,0.0001109533,0.0001540225,0.00001622161,0.00004977007,0.000009521475,0.00006978653,0.00008338394,0.0001030705],"category_scores_gemma":[0.00000170239,0.00008805541,0.00002129576,0.0000580242,0.0002185249,0.000006157413,0.0000535942,0.00008085974,1.54786e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000143983,"about_ca_system_score_gemma":0.00004157624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003676138,"about_ca_topic_score_gemma":0.00006884333,"domain_scores_codex":[0.9993906,0.00003583367,0.0001371942,0.0002100554,0.00004988459,0.0001764012],"domain_scores_gemma":[0.9997571,0.00001039099,0.00006436428,0.00008458957,0.00003359683,0.00004992189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001184557,0.00002447117,0.003866632,0.00003605322,0.00004444509,2.38263e-7,0.0002703414,0.000004413094,0.9431092,0.000109903,0.0004554672,0.05196035],"study_design_scores_gemma":[0.001682295,0.0001428624,0.0224294,0.00001903616,0.00002338311,0.000006461629,0.00009784398,0.0001260853,0.9507402,0.0003193695,0.02428728,0.0001258089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886392,0.008842516,0.00005682271,0.00193997,0.0001744069,0.0002645356,0.00002920689,0.000002933259,0.00005038732],"genre_scores_gemma":[0.9838212,0.01416155,0.00002532812,0.001632466,0.0001462099,0.0000595104,0.000007463898,0.00001055852,0.0001357258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05183454,"threshold_uncertainty_score":0.3590795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005373125667298539,"score_gpt":0.2637172799360422,"score_spread":0.2583441542687437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}