{"id":"W2017923526","doi":"10.1371/journal.pone.0053469","title":"Alteration of Introns in a Hyaluronan Synthase 1 (HAS1) Minigene Convert Pre-Mrna Splicing to the Aberrant Pattern in Multiple Myeloma (MM): MM Patients Harbor Similar Changes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Minigene; Intron; RNA splicing; Exon; Biology; Splice site mutation; Polypyrimidine tract; Exonic splicing enhancer; Exon skipping; Genetics; Alternative splicing; Molecular biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525003,0.00039184,0.0001620033,0.0002347467,0.000123224,0.0002473241,0.0001944407,0.0003250327,0.001051144],"category_scores_gemma":[0.0001647616,0.0001994638,0.0003455866,0.0001432748,0.0001959038,0.0001013122,0.0002036109,0.0004160038,0.0004878162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968775,"about_ca_system_score_gemma":0.0001471325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002114373,"about_ca_topic_score_gemma":0.0003597063,"domain_scores_codex":[0.9998857,0.00002232698,0.00001562146,0.00002789512,0.00003178737,0.00001669552],"domain_scores_gemma":[0.9998177,0.00005783145,0.00007571752,0.00001648162,0.00000956915,0.00002284254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004421323,0.00001479918,0.0002668785,0.0000157691,0.000004351401,0.00006395172,0.00001198871,0.00003525534,0.9987819,0.00004680142,0.00001587995,0.0006981563],"study_design_scores_gemma":[0.00001463994,0.0002252615,0.007878134,0.000009027393,0.00003407111,0.0009553994,0.00001576616,0.0006846218,0.9872258,0.0000379234,0.002913451,0.000005852301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957948,0.0003139642,0.0029741,0.00004955748,0.0000256026,0.00003476873,0.0002905185,0.0001067701,0.0004098846],"genre_scores_gemma":[0.9907879,0.0003211702,0.005606596,0.00005412804,0.0000109467,0.00005228848,0.00129129,0.0000552209,0.001820379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051144,"threshold_uncertainty_score":0.003516495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310650290639547,"score_gpt":0.2364355060143956,"score_spread":0.2133290031080001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}