{"id":"W2017925961","doi":"10.1016/j.addr.2011.10.007","title":"Nanotechnological advances for the delivery of CNS therapeutics","year":2011,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":484,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Nanocarriers; Blood–brain barrier; Drug delivery; Transcytosis; Medicine; Liposome; Nanomedicine; Pharmacology; In vivo; Targeted drug delivery; Endocytosis; Drug; Central nervous system; Nanotechnology; Biology; Materials science; Nanoparticle; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007814268,0.001386338,0.001519034,0.002254126,0.0003995797,0.001021428,0.001119429,0.001341483,0.00398366],"category_scores_gemma":[0.0005744817,0.0004422145,0.0005587206,0.002086863,0.0007058501,0.001562421,0.000906789,0.002336571,0.002883357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008844829,"about_ca_system_score_gemma":0.001180035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195191,"about_ca_topic_score_gemma":0.00343388,"domain_scores_codex":[0.9997359,0.00003526039,0.00002407636,0.00004008264,0.0001356027,0.00002900247],"domain_scores_gemma":[0.9996921,0.0001477066,0.00004541751,0.00001103973,0.00008324865,0.00002044149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006206497,0.0001318722,0.00008379405,0.01503309,0.00006496312,0.0003155064,0.00006946579,0.0007157583,0.02314653,0.009432358,0.02250222,0.9284424],"study_design_scores_gemma":[0.00002109891,0.0000921472,0.000330965,0.001689468,0.00006443035,0.001259941,0.0000355146,0.0002778576,0.005406041,0.002793334,0.9880015,0.00002762832],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000140606,0.9973545,0.0007127219,0.0001810739,0.000337725,0.000007572027,0.000008541108,0.000009025993,0.001248207],"genre_scores_gemma":[0.0008439114,0.9966441,0.0008039285,0.0001361399,0.0002119671,0.00001079097,0.0000161652,0.000002668317,0.001330371],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00398366,"threshold_uncertainty_score":0.01332664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08195102287323605,"score_gpt":0.3304081462074832,"score_spread":0.2484571233342472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}