{"id":"W2017965509","doi":"10.1016/j.jsb.2007.01.012","title":"Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol","year":2007,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Jenny ja Antti Wihurin Rahasto; Natural Sciences and Engineering Research Council of Canada; Syddansk Universitet","keywords":"Desmosterol; Sterol; Membrane; Cholesterol; Lipid raft; Chemistry; Biophysics; Biochemistry; Lipid microdomain; Membrane protein; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005516234,0.0003340588,0.0007941947,0.0001880113,0.00007339094,0.00001971017,0.0003030836,0.0004168021,0.00002281248],"category_scores_gemma":[0.00008644652,0.0002442503,0.0001690221,0.0001182963,0.0002588654,0.00003260835,0.0001217542,0.0003737733,5.439476e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001150358,"about_ca_system_score_gemma":0.00004855761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002124268,"about_ca_topic_score_gemma":0.00001717106,"domain_scores_codex":[0.9977791,0.000213349,0.001066082,0.0003398939,0.0002520458,0.0003495644],"domain_scores_gemma":[0.9980242,0.00007791766,0.001145189,0.0002714157,0.0003381341,0.0001431958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001640495,0.00002953357,0.1898559,0.0001968452,0.0002437856,0.000001127227,0.000163501,0.00002150021,0.8014832,0.000009954611,0.000004457348,0.006349758],"study_design_scores_gemma":[0.001345267,0.003327556,0.2179059,0.0001004193,0.000150069,0.0001166003,0.0001058391,0.000004271926,0.7761616,0.00003853089,0.0005777375,0.0001661769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998498,0.0005345101,0.00002298843,0.00007381888,0.0003607973,0.0003959431,0.00005718892,0.000007131989,0.00004964616],"genre_scores_gemma":[0.9986182,0.00001865476,0.0003127464,0.00006939707,0.0008576373,0.000002412228,0.000058274,0.0000275875,0.0000350185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02805004,"threshold_uncertainty_score":0.9960238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468257412686864,"score_gpt":0.2834057955559198,"score_spread":0.2687232214290512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}