{"id":"W2018005267","doi":"10.1111/j.1471-4159.2007.04619.x","title":"A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of β‐secretase and the production of amyloid‐β<i>in vitro</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Society; Wellcome Trust","keywords":"Cholesterol; Biosynthesis; Biochemistry; Golgi apparatus; Simvastatin; Chemistry; Prenylation; Amyloid precursor protein; Cell biology; In vitro; Enzyme; Biology; Cell; Internal medicine; Pharmacology; Alzheimer's disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558144,0.0007038302,0.0009137069,0.0003881649,0.0001910074,0.0004561665,0.0003681614,0.0004529512,0.002529578],"category_scores_gemma":[0.0001645505,0.0002444448,0.0004058544,0.0003149114,0.0003191296,0.0002146772,0.0001905844,0.0007058333,0.001049504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844913,"about_ca_system_score_gemma":0.0005470281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00204754,"about_ca_topic_score_gemma":0.002913207,"domain_scores_codex":[0.9997688,0.00003610412,0.00003951777,0.00002866705,0.00005905755,0.00006775257],"domain_scores_gemma":[0.9998829,0.00001485946,0.00003070054,0.00001204521,0.00001291554,0.00004657556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007959523,0.0002030994,0.0001652061,0.0001308901,0.00002658359,0.00006689171,0.00001258361,0.00008717138,0.9954755,0.00007257469,0.0001784778,0.002785108],"study_design_scores_gemma":[0.00009639802,0.00150678,0.002900856,0.00001103238,0.0000410545,0.0003808736,0.00001888151,0.0004912975,0.9917682,0.0000246371,0.002752652,0.000007379545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837539,0.008666227,0.001497602,0.0002893573,0.0001491688,0.0001163589,0.001125025,0.0002789939,0.00412329],"genre_scores_gemma":[0.9812363,0.006335328,0.003513238,0.0001897612,0.00003534907,0.0001002872,0.002214278,0.0000366093,0.006338885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529578,"threshold_uncertainty_score":0.00846231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103221414487569,"score_gpt":0.2393953663424914,"score_spread":0.2290732248937345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}