{"id":"W2018006224","doi":"10.1371/journal.pone.0004013","title":"Primordial Germ Cell Specification from Embryonic Stem Cells","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Key Research and Development Program of China; Higher Education Discipline Innovation Project; National Natural Science Foundation of China; Zhejiang University; Bill and Melinda Gates Foundation","keywords":"Epiblast; Biology; Embryoid body; Cell biology; Embryonic stem cell; Cellular differentiation; Stem cell; Germ layer; STELLA (programming language); Germ cell; Germ line development; Cell culture; In vivo; Genetics; Embryo; Embryogenesis; Adult stem cell; Gene; Gastrulation; Induced pluripotent stem cell; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848485,0.0003392446,0.0001895428,0.0003116873,0.0001834934,0.0003191549,0.000293342,0.0002745015,0.00127861],"category_scores_gemma":[0.0001132635,0.0001808735,0.0002458247,0.0002045808,0.0002383478,0.000149064,0.0004227712,0.0006338714,0.0009905348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560365,"about_ca_system_score_gemma":0.0003058226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003180769,"about_ca_topic_score_gemma":0.0007890963,"domain_scores_codex":[0.9998751,0.0000125131,0.00001926184,0.00002607723,0.00005399535,0.00001300046],"domain_scores_gemma":[0.9998924,0.00001902168,0.00002434593,0.00001526364,0.00001868241,0.00003030214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004374826,0.00001021817,0.0006558319,0.0001248617,0.000004663731,0.0001506899,0.00004575348,0.0001593301,0.9933722,0.0006698138,0.0001531348,0.004609867],"study_design_scores_gemma":[0.00001857573,0.0001326101,0.005363259,0.00004758068,0.00002776638,0.0006156057,0.00003545608,0.001572179,0.9569893,0.0002611348,0.03492682,0.000009732928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8493337,0.005884015,0.1201122,0.000245842,0.000209175,0.0003549731,0.003212347,0.0007160292,0.01993182],"genre_scores_gemma":[0.9084327,0.004703789,0.06810142,0.0001770138,0.00003947347,0.0001326448,0.005084922,0.000197415,0.01313055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127861,"threshold_uncertainty_score":0.004277349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04843874970869191,"score_gpt":0.225442212387709,"score_spread":0.1770034626790171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}