{"id":"W2018006224","doi":"10.1371/journal.pone.0004013","title":"Primordial Germ Cell Specification from Embryonic Stem Cells","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Key Research and Development Program of China; Higher Education Discipline Innovation Project; National Natural Science Foundation of China; Zhejiang University; Bill and Melinda Gates Foundation","keywords":"Epiblast; Biology; Embryoid body; Cell biology; Embryonic stem cell; Cellular differentiation; Stem cell; Germ layer; STELLA (programming language); Germ cell; Germ line development; Cell culture; In vivo; Genetics; Embryo; Embryogenesis; Adult stem cell; Gene; Gastrulation; Induced pluripotent stem cell; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009728404,0.0001364677,0.0001631267,0.00003911565,0.00009660781,0.00001738366,0.0002829268,0.0001468704,0.0001108706],"category_scores_gemma":[0.000009840378,0.000142084,0.00007100607,0.00007923933,0.00006977726,0.000004036101,0.000128245,0.0001333177,0.0006649226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003142692,"about_ca_system_score_gemma":0.0001030963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002539533,"about_ca_topic_score_gemma":0.000006440377,"domain_scores_codex":[0.9986452,0.00008329512,0.0001798893,0.0004216762,0.000379642,0.0002902437],"domain_scores_gemma":[0.999135,0.00002034599,0.00008100956,0.0005474258,0.00009615355,0.0001201292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006232693,0.0006729239,0.002051633,0.00002558763,0.00007836257,0.00001059263,0.00003461171,0.000005370583,0.9949012,0.000002088205,0.00199789,0.0001573901],"study_design_scores_gemma":[0.0004455558,0.0001204542,0.003108806,0.00001177734,0.00002592492,0.000001425488,0.00001281139,0.00007261978,0.99147,0.000006117907,0.004561269,0.0001632264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935133,0.0009246808,0.0001443723,0.0001160227,0.00005791305,0.0002958076,0.00005146952,0.00002249154,0.004873981],"genre_scores_gemma":[0.9830704,0.001360429,0.0009458216,0.00006411963,0.0004989938,0.00002704957,0.0001853758,0.00003298968,0.01381477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01044281,"threshold_uncertainty_score":0.8546457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04843874970869191,"score_gpt":0.225442212387709,"score_spread":0.1770034626790171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}