{"id":"W2018008255","doi":"10.1038/nchembio843","title":"Synthetic therapeutic antibodies","year":2006,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Antibody; Computational biology; Function (biology); Computer science; Selection (genetic algorithm); Biology; Immunology; Artificial intelligence; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007891832,0.0001405782,0.0002724459,0.00006149037,0.00004286802,0.000006594149,0.0001192043,0.000485065,0.0003319597],"category_scores_gemma":[0.00007053671,0.00009047429,0.0001265222,0.0001242391,0.0003078975,0.00001314838,0.00005993899,0.0007215742,0.0001384042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002605729,"about_ca_system_score_gemma":0.00003413298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004176107,"about_ca_topic_score_gemma":0.000002024589,"domain_scores_codex":[0.9990427,0.00002799594,0.0001615276,0.0002845826,0.0001335025,0.0003497149],"domain_scores_gemma":[0.9994704,0.0001648319,0.00002649573,0.0001792602,0.00007970458,0.00007931663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002430444,0.0001287483,0.03181941,0.00004735191,0.00004843496,0.0000314773,0.000005819144,5.804223e-8,0.9330893,0.02340432,0.003363818,0.00781826],"study_design_scores_gemma":[0.0007314889,0.000188923,0.02526602,0.00004140173,0.00005248631,0.0003189141,0.000008244511,0.00004437129,0.6383917,0.0173083,0.3174151,0.0002330449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9481238,0.009659261,0.00001771774,0.007827824,0.0001496645,0.0001449737,0.00001992732,0.00007473897,0.03398206],"genre_scores_gemma":[0.9949391,0.0001290591,0.0004504109,0.001519878,0.0005468724,0.00000691445,0.0001398147,0.00001208103,0.002255847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3140513,"threshold_uncertainty_score":0.3741266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246187969612519,"score_gpt":0.322523941417607,"score_spread":0.3100620617214819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}