{"id":"W2018008255","doi":"10.1038/nchembio843","title":"Synthetic therapeutic antibodies","year":2006,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Antibody; Computational biology; Function (biology); Computer science; Selection (genetic algorithm); Biology; Immunology; Artificial intelligence; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005169991,0.0006709088,0.0002596618,0.0004977899,0.0002979318,0.0005787147,0.0005172143,0.000769708,0.008583724],"category_scores_gemma":[0.0004228032,0.0002545143,0.000359075,0.0002846202,0.0003392185,0.0003825455,0.0004898041,0.001310794,0.003981786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005858194,"about_ca_system_score_gemma":0.0004224386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027139,"about_ca_topic_score_gemma":0.0002502968,"domain_scores_codex":[0.9995494,0.000101346,0.000028432,0.00008980108,0.0001509024,0.00008001963],"domain_scores_gemma":[0.9998651,0.00002510176,0.00003041185,0.00002078553,0.00002645096,0.00003217926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003610086,0.0001806854,0.0002316503,0.0006279288,0.00005268515,0.0002493858,0.000074047,0.0007107464,0.9023745,0.02486181,0.01001345,0.06026206],"study_design_scores_gemma":[0.0001270773,0.0005683916,0.000314986,0.00005505013,0.00004730047,0.0008558485,0.00002334644,0.000898555,0.7706705,0.00223246,0.2241908,0.00001556107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.298522,0.05551288,0.3056336,0.005824093,0.006598366,0.001883552,0.004193415,0.003210106,0.3186221],"genre_scores_gemma":[0.7959471,0.01972849,0.07059622,0.003267063,0.000538435,0.001147991,0.003939821,0.0002015707,0.1046332],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008583724,"threshold_uncertainty_score":0.02871543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246187969612519,"score_gpt":0.322523941417607,"score_spread":0.3100620617214819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}