{"id":"W2018055420","doi":"10.1139/o08-035","title":"Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation","year":2008,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Integrin; Adherens junction; Downregulation and upregulation; Cancer research; Biology; Cell biology; Extracellular matrix; Hypoxia-inducible factors; Cell; Chemistry; Cadherin; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002435,0.0001577422,0.0001001402,0.0001297098,0.0001228239,0.0003307251,0.00008170572,0.0001061376,0.000597073],"category_scores_gemma":[0.0001170399,0.000121145,0.0001367699,0.00005440816,0.000182812,0.0001344667,0.0001174478,0.0002209139,0.0002072741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003596908,"about_ca_system_score_gemma":0.0002033882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007533708,"about_ca_topic_score_gemma":0.001131653,"domain_scores_codex":[0.9999082,0.00001339335,0.000006002332,0.00001512789,0.00003350269,0.00002379515],"domain_scores_gemma":[0.9999052,0.00001204632,0.00004422941,0.0000091387,0.00001196339,0.00001739246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004369748,0.0000134588,0.0004511946,0.00001014569,0.000003382528,0.00004822859,0.000008527835,0.00003132505,0.9982768,0.0001530118,0.00003596425,0.0009243814],"study_design_scores_gemma":[0.00001715644,0.0001828346,0.01453176,0.000002486338,0.000009937171,0.0004939869,0.00002397147,0.001177265,0.9803216,0.00008970054,0.003146025,0.000003251294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964681,0.00127115,0.001222671,0.00009073601,0.00001168129,0.00000590562,0.00009238525,0.00004442028,0.0007930745],"genre_scores_gemma":[0.9970426,0.0004598003,0.0005567719,0.00002604361,0.000007274985,0.000008106967,0.0001556017,0.000007862737,0.001735883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007533708,"threshold_uncertainty_score":0.00260973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120526834651831,"score_gpt":0.2254797763675159,"score_spread":0.2142745080209976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}