{"id":"W2018118610","doi":"10.1074/jbc.275.6.4467","title":"PILRα, a Novel Immunoreceptor Tyrosine-based Inhibitory Motif-bearing Protein, Recruits SHP-1 upon Tyrosine Phosphorylation and Is Paired with the Truncated Counterpart PILRβ","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Immunoreceptor tyrosine-based activation motif; SH2 domain; Tyrosine; Biology; Transmembrane domain; Biochemistry; Tyrosine phosphorylation; Protein tyrosine phosphatase; Transmembrane protein; Phosphorylation; Molecular biology; Cell biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004537565,0.0003354848,0.0003455699,0.00002159412,0.0001727641,0.00008224586,0.000345355,0.0003155164,0.0002443185],"category_scores_gemma":[0.0001618184,0.0002035171,0.0001364438,0.0001646055,0.0003162271,0.00001968287,0.0000759763,0.0003724993,0.000003961848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005535778,"about_ca_system_score_gemma":0.0001600547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000165757,"about_ca_topic_score_gemma":0.000001989089,"domain_scores_codex":[0.9984057,0.0000603813,0.0005167372,0.0003983877,0.0002841427,0.0003346285],"domain_scores_gemma":[0.9987546,0.00003919925,0.0004429542,0.0003430964,0.0002711631,0.0001490284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001764131,0.0001845961,0.001083557,0.00004122766,0.00007466687,0.000008780067,0.00002311051,0.00005750585,0.9935321,0.000002642016,0.001186943,0.002040697],"study_design_scores_gemma":[0.001887283,0.0008167138,0.003510203,0.0001946022,0.00003919007,0.0001379616,0.00003801777,0.0001066341,0.9819795,0.00001257106,0.01098687,0.000290407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891977,0.008974428,0.0004112959,0.0008205208,0.00004026415,0.0003485934,0.00007457248,0.0000200825,0.0001125707],"genre_scores_gemma":[0.9973233,0.0002513827,0.001086198,0.0004628376,0.0003395381,0.00003758421,0.0001225128,0.00002951606,0.0003471295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0115526,"threshold_uncertainty_score":0.8299188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642965469211634,"score_gpt":0.2233744495489346,"score_spread":0.2069447948568182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}