{"id":"W2018161141","doi":"10.1021/jm301483h","title":"Structural–Functional Studies of <i>Burkholderia cenocepacia</i> <scp>d</scp>-Glycero-β-<scp>d</scp>-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Cystic Fibrosis Canada; U.S. Department of Energy","keywords":"Chemistry; Burkholderia cenocepacia; Adjuvant; Antibiotics; Kinase; Biochemistry; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421346,0.0003844075,0.0001965736,0.0001012084,0.0001718696,0.0002046573,0.0002462547,0.0002123609,0.000693624],"category_scores_gemma":[0.0001728187,0.00008792205,0.0002292906,0.0001644054,0.0001796155,0.0002277593,0.0001156183,0.0004408919,0.0001723686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003373974,"about_ca_system_score_gemma":0.0002930483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002103727,"about_ca_topic_score_gemma":0.001428323,"domain_scores_codex":[0.9999464,0.00001302066,0.000003365013,0.000008212804,0.00001456706,0.00001456381],"domain_scores_gemma":[0.9999217,0.00001783296,0.00002536225,0.00000495956,0.000009931487,0.00002028997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003675702,0.0001020077,0.00124562,0.0001113258,0.00002131333,0.0001975192,0.00003945268,0.002720857,0.9907013,0.0003791658,0.00007924921,0.004034651],"study_design_scores_gemma":[0.00006273833,0.0006723559,0.009987653,0.0000120124,0.00005133609,0.0008198513,0.000140404,0.006478937,0.975603,0.0002184883,0.005931373,0.00002198625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956736,0.001535841,0.00161082,0.0001387906,0.000009887473,0.00001318278,0.000216213,0.00001942733,0.0007822381],"genre_scores_gemma":[0.9958819,0.001062725,0.001888599,0.00003567537,0.000003760853,0.000005355363,0.0006979972,0.000005011933,0.0004189112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103727,"threshold_uncertainty_score":0.004182994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400618536500701,"score_gpt":0.2192869488382135,"score_spread":0.2052807634732065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}