{"id":"W2018164908","doi":"10.1074/jbc.m310721200","title":"Calphostin-C Induction of Vascular Smooth Muscle Cell Apoptosis Proceeds through Phospholipase D and Microtubule Inhibition","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Calphostin C; Vascular smooth muscle; Cell biology; Calphostin; PLD2; Apoptosis; Microtubule polymerization; Biology; Phospholipase C; Phospholipase D; Phosphatidic acid; Protein kinase C; Microtubule; Signal transduction; Biochemistry; Endocrinology; Tubulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211975,0.0003083169,0.0002234884,0.000305723,0.0002198297,0.0002473552,0.0001543235,0.0002125772,0.0007309435],"category_scores_gemma":[0.0001335405,0.0001274187,0.0002894637,0.0002228428,0.0001517452,0.0001325241,0.0002041696,0.0006004929,0.0001899232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005331137,"about_ca_system_score_gemma":0.0003387105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009374415,"about_ca_topic_score_gemma":0.001338479,"domain_scores_codex":[0.9998782,0.00001802815,0.00001529836,0.00002497514,0.00003552606,0.00002800257],"domain_scores_gemma":[0.9999156,0.0000175296,0.00002243188,0.00001099506,0.0000144914,0.00001896727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228912,0.00002803354,0.0001850131,0.00005612226,0.000006929431,0.00006055297,0.00001170311,0.00005322262,0.9975485,0.0001038788,0.00003847036,0.001784657],"study_design_scores_gemma":[0.00004446819,0.0001860906,0.004139393,0.000007544917,0.00001148481,0.0001438238,0.00001219999,0.001081825,0.9915335,0.00005246874,0.002784458,0.000002750403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862667,0.006115015,0.004062897,0.0002134385,0.00006781,0.00008098135,0.0003616744,0.00009870184,0.002732722],"genre_scores_gemma":[0.9888995,0.003515791,0.00328127,0.0001348174,0.00001991897,0.0001034375,0.0006015934,0.000009759937,0.003433883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009374415,"threshold_uncertainty_score":0.003868043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394655744265781,"score_gpt":0.2290161679987029,"score_spread":0.2150696105560451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}