{"id":"W2018172746","doi":"10.1002/eji.200535277","title":"A novel PKC regulates ERK activation and degranulation of cytotoxic T lymphocytes: Plasticity in PKC regulation of ERK","year":2006,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ontario Genomics; University of Alberta","funders":"National Cancer Institute; Fondation pour la Recherche Médicale","keywords":"CTL*; MAPK/ERK pathway; Degranulation; Protein kinase C; Cell biology; Cytotoxic T cell; Biology; Kinase; Receptor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006353582,0.0002278171,0.0006167673,0.0006053408,0.00008124184,0.000007554965,0.000261759,0.0002178284,0.00008985074],"category_scores_gemma":[0.0002046429,0.0002040045,0.0001202355,0.0002904374,0.000592323,0.0002090481,0.00009594009,0.0003726741,0.00001558267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008513653,"about_ca_system_score_gemma":0.00009193791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000157856,"about_ca_topic_score_gemma":0.00002084786,"domain_scores_codex":[0.9973345,0.0007246349,0.001358475,0.0002228615,0.00006502753,0.0002944376],"domain_scores_gemma":[0.9976499,0.0003590969,0.00149503,0.0002071429,0.0002748839,0.00001394123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00132044,0.0003650963,0.003454297,0.00003010085,0.0001691488,0.000007605087,0.0003923049,0.0004386361,0.9898554,0.0009372561,0.00007287113,0.00295685],"study_design_scores_gemma":[0.004461268,0.0007342413,0.3050859,0.0001729722,0.00004700374,0.0004072272,0.0001565455,0.00002632466,0.6880181,0.0003169595,0.0004424343,0.0001310706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993655,0.002365945,0.002823028,0.00009461146,0.0003520845,0.0001462821,0.000009540028,0.00001516091,0.000538369],"genre_scores_gemma":[0.9987689,0.0001422965,0.0007340118,0.00001525604,0.00004447483,0.000001161425,0.00003405107,0.00002629161,0.0002335086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3018373,"threshold_uncertainty_score":0.8319061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086726321025688,"score_gpt":0.199559769168206,"score_spread":0.1886925059579491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}