{"id":"W2018172746","doi":"10.1002/eji.200535277","title":"A novel PKC regulates ERK activation and degranulation of cytotoxic T lymphocytes: Plasticity in PKC regulation of ERK","year":2006,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ontario Genomics; University of Alberta","funders":"National Cancer Institute; Fondation pour la Recherche Médicale","keywords":"CTL*; MAPK/ERK pathway; Degranulation; Protein kinase C; Cell biology; Cytotoxic T cell; Biology; Kinase; Receptor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413011,0.0004123034,0.0001708843,0.000188762,0.0001957983,0.0004593169,0.000240697,0.0002735547,0.001015591],"category_scores_gemma":[0.000157067,0.0001332189,0.0002541794,0.0001278695,0.0002330667,0.0004920808,0.0002872079,0.0006468638,0.000356156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988886,"about_ca_system_score_gemma":0.0001884376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001198751,"about_ca_topic_score_gemma":0.0002729136,"domain_scores_codex":[0.9998606,0.00001633345,0.00001745236,0.00003745624,0.00002606086,0.00004202516],"domain_scores_gemma":[0.9998485,0.00001610231,0.00004001203,0.00003305985,0.00002241721,0.00003987649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009151353,0.00002015776,0.0002409259,0.00001398114,0.00000158351,0.00004878432,0.000004152171,0.00003090781,0.9985715,0.00008863429,0.000006522254,0.0008812652],"study_design_scores_gemma":[0.0000258585,0.0001507347,0.01039691,0.000005724101,0.00001464842,0.0007409445,0.00001944971,0.001093733,0.9865065,0.0001408592,0.0008996404,0.000004883371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948369,0.0008538151,0.003498674,0.00007409509,0.00001649054,0.00001591998,0.00008308106,0.00003665833,0.0005843423],"genre_scores_gemma":[0.9961772,0.0006108851,0.001920733,0.00001808248,0.00001349906,0.0000205464,0.0001755868,0.000008890775,0.001054557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015591,"threshold_uncertainty_score":0.003397524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086726321025688,"score_gpt":0.199559769168206,"score_spread":0.1886925059579491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}