{"id":"W2018237098","doi":"10.1038/nrc2869","title":"Cartilage tumours and bone development: molecular pathology and possible therapeutic targets","year":2010,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; SickKids Foundation; Mount Sinai Hospital","funders":"","keywords":"Chondrosarcoma; Cancer research; Hedgehog signaling pathway; Cartilage; Hedgehog; Pathology; Biology; Medicine; Signal transduction; Anatomy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003536681,0.0006870719,0.003210379,0.0001690487,0.00009851744,0.00003464859,0.0001002918,0.0009474381,0.0001169507],"category_scores_gemma":[0.0000721013,0.0004380872,0.000321296,0.0002544961,0.0001155687,0.00004687853,0.00008797952,0.001646591,0.0000332202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269826,"about_ca_system_score_gemma":0.0003915265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006574694,"about_ca_topic_score_gemma":0.00004398828,"domain_scores_codex":[0.997751,0.0001600431,0.0006812544,0.0007602427,0.000226322,0.0004211352],"domain_scores_gemma":[0.9987771,0.00006786913,0.0004328181,0.0003849671,0.00007312137,0.0002641607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005279532,0.00007063445,0.0002391534,0.01515646,0.0001196552,0.0006956775,0.00005394821,1.528791e-9,0.00001673025,0.00006755898,0.0003643613,0.9832106],"study_design_scores_gemma":[0.0004859696,0.00005771482,0.000408303,0.01820257,0.002962312,0.001191672,0.000001828242,7.305476e-8,0.00004779517,0.00001982545,0.976258,0.0003639389],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000354523,0.9967191,0.000001475796,0.0001717574,0.0002858844,0.002104367,0.00003782401,0.00003335382,0.000291756],"genre_scores_gemma":[0.0001927983,0.996342,0.0007649766,0.0009222658,0.0001406942,0.0009505169,0.0001243139,0.00009833642,0.0004641231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9828466,"threshold_uncertainty_score":0.9998071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02550217506779571,"score_gpt":0.3558541349164441,"score_spread":0.3303519598486483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}