{"id":"W2018246719","doi":"10.1016/j.cmet.2015.02.010","title":"Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection","year":2015,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Minerva Foundation","keywords":"Biology; Selection (genetic algorithm); Start codon; Cell biology; Gene; Genetics; Computational biology; Political science; Computer science; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524226,0.0001607679,0.0002430372,0.0001233201,0.00003017287,0.00002010952,0.00008221083,0.0001278955,0.000004985407],"category_scores_gemma":[0.00003339617,0.0001596247,0.00003861508,0.0002438312,0.00003374807,0.00001589913,0.0000259914,0.00005477486,0.000001173122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005010852,"about_ca_system_score_gemma":0.00007238437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002184013,"about_ca_topic_score_gemma":0.0003251558,"domain_scores_codex":[0.9990044,0.00007902286,0.0002747781,0.0003396095,0.0001305313,0.0001716503],"domain_scores_gemma":[0.9995165,0.000003119063,0.00006306043,0.0001481794,0.0001687338,0.0001004366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135881,0.00006257954,0.0004543386,0.00001883298,0.00001421431,1.926194e-7,0.0001698564,0.007688939,0.9863753,0.0002823949,0.0003782007,0.004419285],"study_design_scores_gemma":[0.0007939744,0.00006192768,0.001914319,0.000008820683,0.00002459336,0.00000372546,0.00002699263,0.0003953319,0.8728365,0.00002227974,0.1237501,0.0001614386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760929,0.01352809,0.009222433,0.00007656989,0.000775855,0.0001801214,0.00003871518,0.00001255946,0.00007276314],"genre_scores_gemma":[0.9921346,0.001004896,0.005094954,0.00006274303,0.001086811,0.00002860828,0.0001315703,0.00002113658,0.0004346446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1233719,"threshold_uncertainty_score":0.6509308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936966255059733,"score_gpt":0.210501830090309,"score_spread":0.2011321675397117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}