{"id":"W2018264204","doi":"10.1074/jbc.m111.317453","title":"Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; St. Michael's Hospital; Toronto General Hospital; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fundación Bancaria Ibercaja; Novo Nordisk; Canadian Diabetes Association","keywords":"Steatohepatitis; Endocrinology; Internal medicine; Insulin resistance; Steatosis; Fatty liver; Janus kinase 2; Biology; Hepatocyte; Metabolic syndrome; Insulin; Medicine; Diabetes mellitus; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787121,0.0006153918,0.0004482147,0.0003298035,0.0001903031,0.0002981659,0.0002779017,0.0003513306,0.001548855],"category_scores_gemma":[0.0001314213,0.0002280609,0.0002068048,0.0001791726,0.0003332045,0.0002585556,0.0002522079,0.001084243,0.0003221022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344596,"about_ca_system_score_gemma":0.0003784389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002754327,"about_ca_topic_score_gemma":0.0005743631,"domain_scores_codex":[0.9998534,0.00002449166,0.00001827243,0.00002525663,0.00003341177,0.00004520802],"domain_scores_gemma":[0.9998088,0.00001511152,0.00004628545,0.00001430862,0.00001090737,0.0001046004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001413372,0.0002540719,0.0002417756,0.0001090926,0.00001733457,0.00006407865,0.00001441171,0.0001149043,0.9950466,0.000128308,0.0001115682,0.002484626],"study_design_scores_gemma":[0.0006292463,0.004704543,0.01596233,0.00004087372,0.00009867213,0.0006459149,0.0001080412,0.00204795,0.9716536,0.0002754555,0.003807338,0.00002604192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927816,0.002864877,0.002149099,0.0002356086,0.000146308,0.00004755583,0.0004102422,0.0002251417,0.001139664],"genre_scores_gemma":[0.9937422,0.001436388,0.001293932,0.0001389628,0.00003818133,0.00007818499,0.0006172532,0.00003577939,0.002619192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548855,"threshold_uncertainty_score":0.005181432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417208900036972,"score_gpt":0.2589832191570434,"score_spread":0.2248111301566736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}