{"id":"W2018274205","doi":"10.1038/mt.2008.62","title":"Treatment of Obesity and Diabetes in Mice by Transplant of Gut Cells Engineered to Produce Leptin","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"Leptin; Endocrinology; Internal medicine; Diabetes mellitus; Adipose tissue; Medicine; Leptin receptor; Adipokine; Transplantation; Mifepristone; Diet-induced obese; Biology; Obesity; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002663557,0.000854745,0.0006338375,0.0006440357,0.0002223816,0.0004776348,0.0003407592,0.0007864914,0.001266913],"category_scores_gemma":[0.0001715228,0.0002974476,0.0006036199,0.0003076785,0.0006022758,0.0005278182,0.0002613296,0.00217241,0.0003495597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520487,"about_ca_system_score_gemma":0.0003148984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002434087,"about_ca_topic_score_gemma":0.0004797186,"domain_scores_codex":[0.9998176,0.00002442755,0.0000177382,0.00003554716,0.00004801231,0.0000566572],"domain_scores_gemma":[0.9998375,0.00002263665,0.00005923936,0.00001833783,0.000009173496,0.0000530885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001335479,0.0003193586,0.0001852133,0.00007896038,0.00003484106,0.0001348215,0.00002237025,0.0002835552,0.9908311,0.0007123526,0.0001877772,0.005874296],"study_design_scores_gemma":[0.0006899901,0.002703232,0.002033935,0.00003203094,0.0001425592,0.0005083177,0.00006355077,0.001795303,0.9865154,0.0005308283,0.004963979,0.00002079221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835966,0.004224815,0.007190252,0.001034122,0.0004892884,0.00009385757,0.0005181981,0.0002992809,0.002553591],"genre_scores_gemma":[0.9803161,0.005164552,0.007602315,0.0002809184,0.0001231332,0.0001642801,0.0005679341,0.0001014311,0.005679253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266913,"threshold_uncertainty_score":0.004238307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303491593349777,"score_gpt":0.2155875109113448,"score_spread":0.202552594977847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}