{"id":"W2018288116","doi":"10.1371/journal.pone.0027780","title":"Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; York University; Center for AIDS Research, University of Washington; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Veterans Affairs","keywords":"Epitope; Immunoglobulin light chain; Complementarity determining region; Gene; Biology; Monoclonal antibody; Genetics; Mimotope; Context (archaeology); Conformational epitope; Antibody; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007969907,0.0001833491,0.0001152369,0.0001042433,0.00009211309,0.0002036488,0.0001329756,0.0001738507,0.0005487051],"category_scores_gemma":[0.0001019552,0.00009463212,0.0001396947,0.00009820919,0.0001200304,0.00007925019,0.0001228116,0.0002172756,0.0001742985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248623,"about_ca_system_score_gemma":0.00009349334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006996905,"about_ca_topic_score_gemma":0.0009533545,"domain_scores_codex":[0.9998946,0.00001482923,0.000005233364,0.00002603018,0.00002792894,0.00003135715],"domain_scores_gemma":[0.9999645,0.000008596247,0.000009640909,0.000005095687,0.000005816095,0.000006334444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006121265,0.00001357574,0.001984606,0.00001164586,0.000005601907,0.00004347558,0.00002504612,0.00007159201,0.9958905,0.00007502263,0.00002155917,0.001796209],"study_design_scores_gemma":[0.00005477504,0.000908936,0.08448994,0.00001705699,0.00004473283,0.001972752,0.0001454282,0.002231693,0.9033748,0.0002183515,0.006531526,0.000009980272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981332,0.0002729942,0.000940521,0.000009272491,0.000003005036,0.000008578876,0.00008030771,0.00001196462,0.0005401906],"genre_scores_gemma":[0.9983528,0.0001263674,0.0009426404,0.00003102069,0.000002180504,0.00000555211,0.0002048426,0.000003038339,0.000331611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006996905,"threshold_uncertainty_score":0.001835525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1087276520329558,"score_gpt":0.2821249641131049,"score_spread":0.1733973120801491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}