{"id":"W2018293376","doi":"10.1016/j.dnarep.2010.12.008","title":"HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase","year":2011,"lang":"en","type":"article","venue":"DNA repair","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Francis Crick Institute","keywords":"Somatic hypermutation; Biology; Ubiquitin ligase; Somatic cell; Ubiquitin; Proliferating cell nuclear antigen; Genetics; DNA repair; DNA ligase; DNA; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237604,0.0001336335,0.000168863,0.00004106529,0.00006701452,0.00001301306,0.00009715807,0.00009193967,0.000008149072],"category_scores_gemma":[0.0001447652,0.0001342254,0.00006323345,0.00003985966,0.0001142215,0.0000166239,0.0000756959,0.000032722,6.681971e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006632632,"about_ca_system_score_gemma":0.00003354962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003443579,"about_ca_topic_score_gemma":0.00003917049,"domain_scores_codex":[0.9990857,0.00006145726,0.0002255403,0.0003553163,0.0001230857,0.0001489414],"domain_scores_gemma":[0.9992971,0.0000232536,0.0001769183,0.0002480145,0.0001708681,0.00008388569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002666041,0.0001727539,0.001089735,0.0001826052,0.00008191792,0.00001132183,0.0008724731,0.00000144811,0.991389,0.00386933,0.00003976437,0.002022989],"study_design_scores_gemma":[0.0007181224,0.0005519232,0.005935376,0.00002815042,0.00004133422,0.00002920162,0.0006996347,0.001495097,0.9885282,0.001691884,0.0001142025,0.0001668558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973034,0.000127693,0.001652137,0.00004361038,0.000117576,0.0002920305,0.00005943396,0.0000350147,0.0003691404],"genre_scores_gemma":[0.9898959,0.00002571793,0.009587314,0.00007552929,0.0001014807,0.00004191915,0.00006102598,0.00002114846,0.000189932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007935178,"threshold_uncertainty_score":0.5473551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573558489796279,"score_gpt":0.2642609887536314,"score_spread":0.2385254038556686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}