{"id":"W2018371308","doi":"10.1016/j.bmcl.2009.09.069","title":"Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acadia University; Université Sainte-Anne","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Nova Scotia Health Research Foundation","keywords":"Chemistry; Potency; Conjugate; Cytotoxicity; Pharmacology; Selectivity; In vitro; Topoisomerase; Stereochemistry; Chemical synthesis; Biochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581425,0.0002158706,0.0002843218,0.00003631068,0.00003555555,0.000008718274,0.0001800785,0.0001344278,0.00007195774],"category_scores_gemma":[0.00009704276,0.000202346,0.00006449148,0.00009272542,0.0001787547,0.000005866489,0.00003866661,0.00007197292,0.000001212793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002383121,"about_ca_system_score_gemma":0.00008372187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001489007,"about_ca_topic_score_gemma":3.873791e-7,"domain_scores_codex":[0.9988157,0.00003299121,0.0003457168,0.000333272,0.0002598111,0.0002124973],"domain_scores_gemma":[0.9992785,0.00003343618,0.0002297578,0.0002893687,0.00008077238,0.00008815561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001849615,0.0000839595,0.00006529743,0.0001152661,0.00009127342,0.000002881571,0.0001255403,0.000005263435,0.9964126,0.000005426849,0.00007813542,0.002829445],"study_design_scores_gemma":[0.0009002542,0.0002697433,0.0006830777,0.0001070138,0.0001565945,0.00005734611,0.0001644832,0.00009445124,0.9972146,0.00002663333,0.0001352674,0.0001905216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897664,0.001000145,0.007785938,0.001133537,0.00006680715,0.0001778701,0.00002323527,0.000008066356,0.00003798147],"genre_scores_gemma":[0.9968833,0.0004108039,0.00141418,0.001078051,0.000109553,0.000009383549,0.00003958958,0.00002124808,0.00003391091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00711686,"threshold_uncertainty_score":0.825143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619255832685222,"score_gpt":0.2722280305617613,"score_spread":0.2460354722349091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}