{"id":"W2018406581","doi":"10.1002/prot.10453","title":"A second binding site revealed by C‐terminal truncation of calpain small subunit, a penta‐EF‐hand protein","year":2003,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Canadian Light Source (Canada); Queen's University","funders":"Canada Research Chairs","keywords":"Calpain; Protein subunit; Oligomer; Chemistry; Binding site; Protein structure; Biochemistry; Biophysics; Stereochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017838,0.0002292878,0.0001960465,0.0001266554,0.0002197653,0.00006690023,0.0000621171,0.0002587143,0.0002023259],"category_scores_gemma":[0.0001216343,0.0001939742,0.00007597441,0.0001923656,0.0001197445,0.00002589545,0.0000347653,0.0001462767,0.000004070545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002535355,"about_ca_system_score_gemma":0.00008289282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008017053,"about_ca_topic_score_gemma":0.00006637298,"domain_scores_codex":[0.998809,0.0001037171,0.0004636292,0.0002255197,0.0001829029,0.0002152644],"domain_scores_gemma":[0.9991525,0.000008155706,0.0003371899,0.0002400042,0.0001447894,0.0001173922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002822749,0.00004363338,0.001521846,0.0004238855,0.00005281217,3.353574e-7,0.0001787645,0.00000886275,0.9898857,0.0002662633,0.0009898271,0.00634583],"study_design_scores_gemma":[0.003953619,0.001654289,0.003888786,0.0001403236,0.0001153262,0.0001745438,0.000558362,0.00206049,0.8426733,0.0005291248,0.1434829,0.0007688857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540094,0.0002323321,0.04375765,0.00005715503,0.0001454845,0.001200482,0.0001618155,0.00002038093,0.0004153494],"genre_scores_gemma":[0.9896826,0.00001781389,0.006765142,0.0001513158,0.00007261341,0.00005828922,0.0008446405,0.00002067687,0.002386918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1472124,"threshold_uncertainty_score":0.7910038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005274816758375042,"score_gpt":0.1911659954655072,"score_spread":0.1858911787071322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}