{"id":"W2018406581","doi":"10.1002/prot.10453","title":"A second binding site revealed by C‐terminal truncation of calpain small subunit, a penta‐EF‐hand protein","year":2003,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Canadian Light Source (Canada); Queen's University","funders":"Canada Research Chairs","keywords":"Calpain; Protein subunit; Oligomer; Chemistry; Binding site; Protein structure; Biochemistry; Biophysics; Stereochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058132,0.0003013024,0.0004219532,0.0001363686,0.0002360028,0.0003023746,0.0003498781,0.000618431,0.001533358],"category_scores_gemma":[0.0002015382,0.0002079069,0.0003961342,0.000119537,0.0002713227,0.0002364871,0.000249833,0.0008868192,0.000486099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005051066,"about_ca_system_score_gemma":0.0003078581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107879,"about_ca_topic_score_gemma":0.001276308,"domain_scores_codex":[0.999854,0.00001117046,0.000009541376,0.00005454816,0.00004226918,0.00002849004],"domain_scores_gemma":[0.999833,0.00002598666,0.00004773528,0.00002088827,0.0000182775,0.00005415495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038423,0.00002305745,0.0003112307,0.00002701644,0.000003877117,0.0001645247,0.00001774621,0.00006829767,0.9986277,0.0001086521,0.00004572773,0.000498372],"study_design_scores_gemma":[0.00004425114,0.0001200707,0.009858486,0.000009771837,0.00002071657,0.001437088,0.00003100485,0.001917119,0.9836142,0.0001362783,0.002799171,0.00001192888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944521,0.0005211278,0.003902254,0.0001203252,0.00003305074,0.00001160416,0.0002055412,0.00005340602,0.0007006057],"genre_scores_gemma":[0.990529,0.0001985219,0.006514295,0.0001059442,0.000009407865,0.00002142312,0.0006651298,0.00002144683,0.001934736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533358,"threshold_uncertainty_score":0.005129576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005274816758375042,"score_gpt":0.1911659954655072,"score_spread":0.1858911787071322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}