{"id":"W2018472638","doi":"10.1021/nn4046024","title":"Sustained Drug Release in Nanomedicine: A Long-Acting Nanocarrier-Based Formulation for Glaucoma","year":2014,"lang":"en","type":"article","venue":"ACS Nano","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Nanocarriers; Nanomedicine; Drug delivery; Drug; Pharmacology; Latanoprost; Nanotechnology; Liposome; In vivo; Drug carrier; Materials science; Chemistry; Medicine; Nanoparticle; Intraocular pressure; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003352415,0.0003479609,0.0002161583,0.0004539177,0.0003089357,0.0003998013,0.0002486129,0.0007066416,0.001584083],"category_scores_gemma":[0.0002342566,0.0001648239,0.0003073798,0.0001523962,0.0003646794,0.0006649098,0.0003112238,0.0007283891,0.0008040979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004015618,"about_ca_system_score_gemma":0.0002844878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005047269,"about_ca_topic_score_gemma":0.0008108381,"domain_scores_codex":[0.9998739,0.00002711268,0.00001036213,0.00002768226,0.00004345298,0.00001740719],"domain_scores_gemma":[0.9999171,0.00001655318,0.00002913265,0.000006791528,0.00001461882,0.00001573864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009142346,0.0000976853,0.0001043133,0.0002817253,0.00001227891,0.0002744066,0.00008603836,0.0002660934,0.9636769,0.0009635655,0.0005872148,0.0335583],"study_design_scores_gemma":[0.0001743756,0.002056379,0.001823535,0.00008283549,0.00007077508,0.002350754,0.00004986059,0.003304388,0.932934,0.0006105842,0.05648267,0.00005986318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7076757,0.07718094,0.1801073,0.006279556,0.001382861,0.001222497,0.0006021986,0.002000436,0.02354849],"genre_scores_gemma":[0.8820872,0.01444567,0.0873076,0.001435506,0.0002487406,0.0002574729,0.0001948604,0.0002242258,0.0137987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584083,"threshold_uncertainty_score":0.00529927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006310139932910516,"score_gpt":0.2494477619297047,"score_spread":0.2431376219967941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}