{"id":"W2018538469","doi":"10.1016/j.neuint.2007.04.010","title":"Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration","year":2007,"lang":"en","type":"review","venue":"Neurochemistry International","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Japan Society for the Promotion of Science","keywords":"Biology; Pleckstrin homology domain; Hereditary spastic paraplegia; Excitotoxicity; Cell biology; Guanine nucleotide exchange factor; Missense mutation; Genetics; Mutation; Biochemistry; Gene; Glutamate receptor; GTPase; Signal transduction; Phenotype; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801187,0.0001952804,0.0005186102,0.0001970009,0.00001514187,0.00001125549,0.0001090465,0.000210642,0.00003580061],"category_scores_gemma":[0.00008973312,0.0001849241,0.00007286928,0.0001513661,0.00008175248,0.00004210349,0.00009777603,0.0002872246,8.760646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014883,"about_ca_system_score_gemma":0.0001856023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007706395,"about_ca_topic_score_gemma":0.000002711738,"domain_scores_codex":[0.9983347,0.00003365003,0.0006802795,0.0003468469,0.0004746616,0.000129837],"domain_scores_gemma":[0.9992247,0.00005830028,0.0002930774,0.0001608166,0.0001875744,0.00007548468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001431123,0.0002174204,0.0006590661,0.01350146,0.0001685342,0.00002666433,0.00002821713,0.00000933666,0.3559664,0.0004664291,0.0000147468,0.6287986],"study_design_scores_gemma":[0.005045703,0.0006258782,0.01964406,0.01987505,0.001127772,0.0007092942,0.0000525352,0.003619149,0.6886705,0.0001181832,0.2590902,0.001421691],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6823753,0.3152824,0.0006471926,0.0001295428,0.0001122054,0.0005639407,0.00004090983,0.0000136038,0.0008349409],"genre_scores_gemma":[0.2843071,0.7130406,0.0006851356,0.00004276278,0.000117634,0.00005304057,0.001502262,0.00004958724,0.0002018837],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6273769,"threshold_uncertainty_score":0.7540987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03858441230795062,"score_gpt":0.330158615675638,"score_spread":0.2915742033676874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}