{"id":"W2018556051","doi":"10.1021/jm3015712","title":"Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1<i>H</i>-benzimidazole Derivatives","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Androgen receptor; Antiandrogens; Bicalutamide; Enzalutamide; Antiandrogen; LNCaP; Flutamide; Thio-; Prostate cancer; Benzimidazole; Androgen Receptor Antagonists; Androgen; Stereochemistry; Pharmacology; Cancer; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003417315,0.0008693409,0.00057814,0.0004195443,0.0002350076,0.000450293,0.0005118455,0.0003239386,0.001376652],"category_scores_gemma":[0.000297078,0.0001613072,0.0007036971,0.0003396631,0.0001918583,0.0002201735,0.0003285398,0.0004080871,0.0003488132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000512959,"about_ca_system_score_gemma":0.0006177836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002245259,"about_ca_topic_score_gemma":0.004787454,"domain_scores_codex":[0.9998395,0.00004013634,0.000005803336,0.00002349457,0.00005370011,0.00003722189],"domain_scores_gemma":[0.9999483,0.0000152237,0.00001369479,0.000003405032,0.000008040408,0.00001143534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001932126,0.001368977,0.005376166,0.0008807893,0.0002369554,0.001042698,0.0001077647,0.130245,0.7310763,0.003701502,0.003393623,0.1206381],"study_design_scores_gemma":[0.001062454,0.007151443,0.007786418,0.00009128269,0.0004877663,0.002291226,0.0001012037,0.2598002,0.6935672,0.002147597,0.02533714,0.0001761051],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9326898,0.006200376,0.04399894,0.000445814,0.00007575066,0.000734356,0.002672109,0.001272208,0.01191068],"genre_scores_gemma":[0.9661449,0.002457122,0.02687084,0.000147556,0.000008497294,0.0001702551,0.001996432,0.00003946184,0.002164972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002245259,"threshold_uncertainty_score":0.004605353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0247684380299912,"score_gpt":0.2794613819679381,"score_spread":0.2546929439379469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}