{"id":"W2018556051","doi":"10.1021/jm3015712","title":"Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1<i>H</i>-benzimidazole Derivatives","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Androgen receptor; Antiandrogens; Bicalutamide; Enzalutamide; Antiandrogen; LNCaP; Flutamide; Thio-; Prostate cancer; Benzimidazole; Androgen Receptor Antagonists; Androgen; Stereochemistry; Pharmacology; Cancer; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00074115,0.000167102,0.0003944467,0.00003979141,0.0001784661,0.00001200994,0.0002292889,0.00009827564,0.0005861242],"category_scores_gemma":[0.0003077944,0.00007992134,0.0001545667,0.0002871808,0.0003022953,0.0001509123,0.00009805267,0.0005593181,0.000003799111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182396,"about_ca_system_score_gemma":0.0004814175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001522523,"about_ca_topic_score_gemma":3.659647e-7,"domain_scores_codex":[0.9978209,0.00006083188,0.0007515834,0.0001321232,0.0009858934,0.0002487423],"domain_scores_gemma":[0.998173,0.0001826024,0.0007915495,0.0001870429,0.0005512142,0.0001145651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005456351,0.0001106788,0.0169877,0.0002578495,0.000401717,0.000005089391,0.004260759,0.00001978632,0.9676318,0.000002700931,0.002392453,0.007383833],"study_design_scores_gemma":[0.002269526,0.0003039735,0.007648805,0.001222336,0.0001691321,0.00007717605,0.01021371,0.00004772644,0.9739492,0.00003256877,0.003972614,0.00009322534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993735,0.002746019,0.0005687893,0.001744584,0.0001667184,0.0002377138,0.000004934735,0.000005846224,0.000790404],"genre_scores_gemma":[0.9966776,0.0002639001,0.00190168,0.0001066205,0.0004021168,0.000008715706,0.00001249122,0.00001772176,0.0006091815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009338892,"threshold_uncertainty_score":0.6417649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0247684380299912,"score_gpt":0.2794613819679381,"score_spread":0.2546929439379469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}