{"id":"W2018604540","doi":"10.1124/mol.107.039008","title":"Lipid Composition Alters Drug Action at the Nicotinic Acetylcholine Receptor","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Drug action; Chemistry; Acetylcholine receptor; Nicotinic acetylcholine receptor; Pharmacology; Nicotinic agonist; Acetylcholine; Drug; Action (physics); Composition (language); Receptor; Biochemistry; Biology; Philosophy; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001167726,0.000338865,0.0002583038,0.00008248342,0.0003127623,0.00002046853,0.0004710424,0.0002277335,0.0005548401],"category_scores_gemma":[0.00005152505,0.0002912166,0.0002422854,0.0002363066,0.0002548423,0.00000802669,0.0004679568,0.0003902566,0.0003152404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001546537,"about_ca_system_score_gemma":0.00007089826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001696906,"about_ca_topic_score_gemma":0.00007779871,"domain_scores_codex":[0.9974256,0.0004612078,0.0004859543,0.0006717166,0.0002724616,0.0006831198],"domain_scores_gemma":[0.9988388,0.00008127831,0.0002514335,0.000503735,0.0001363356,0.0001883955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004461175,0.0001962862,0.0004904401,0.00001054353,0.0001850688,0.000002445702,0.00006604582,0.0001683615,0.9131383,0.00001599993,0.08304786,0.002232541],"study_design_scores_gemma":[0.001507283,0.0001533582,0.0001638036,0.000003959743,0.00008630159,0.00005657241,0.00006208879,0.00003321609,0.7786703,0.000003164153,0.2190142,0.0002458055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865122,0.001017842,0.00566866,0.002543963,0.002402597,0.0007078128,0.00002004655,0.00006196748,0.00106485],"genre_scores_gemma":[0.9897257,0.0004116892,0.0005920083,0.005084607,0.001452351,0.00006473569,0.0004205169,0.00007753186,0.002170862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1359663,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155793764712971,"score_gpt":0.3165190804039654,"score_spread":0.3049611427568357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}