{"id":"W2018623907","doi":"10.1074/jbc.m801401200","title":"Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Glyceraldehyde 3-phosphate dehydrogenase; AP site; DNA-(apurinic or apyrimidinic site) lyase; AP endonuclease; DNA damage; Biology; Biochemistry; Dehydrogenase; DNA repair; DNA; Base excision repair; Gene knockdown; Molecular biology; Endonuclease; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009659994,0.0002544794,0.0001136322,0.0000917485,0.0001280082,0.0002321005,0.0001615503,0.0001771888,0.001241961],"category_scores_gemma":[0.0001212621,0.0001143075,0.0001560085,0.0001183592,0.0002001188,0.0001177469,0.0001556954,0.0001662669,0.0005403746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632403,"about_ca_system_score_gemma":0.0001211501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006062776,"about_ca_topic_score_gemma":0.0005804708,"domain_scores_codex":[0.9999248,0.00001509116,0.00000395777,0.0000267984,0.0000168716,0.00001249007],"domain_scores_gemma":[0.999959,0.000008075852,0.000009647718,0.000008045318,0.000005559118,0.000009620468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714796,0.00002159049,0.001218513,0.00003561548,0.000008727749,0.00007225302,0.00001443909,0.00006281979,0.9946102,0.0002506638,0.000105699,0.003428037],"study_design_scores_gemma":[0.00001038105,0.0001026094,0.00716611,0.000004336061,0.00001181707,0.0003912503,0.00001662006,0.0004920002,0.9873593,0.0001231854,0.004319237,0.000003193279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851204,0.004782986,0.007217711,0.0002121835,0.0000622888,0.00001419567,0.0002320544,0.000118871,0.002239412],"genre_scores_gemma":[0.9961995,0.0005660548,0.001170066,0.0000252896,0.000006331452,0.000005541679,0.000246116,0.000008057975,0.001773082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241961,"threshold_uncertainty_score":0.004154742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379140942744393,"score_gpt":0.2521048853580002,"score_spread":0.2383134759305562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}