{"id":"W2018623907","doi":"10.1074/jbc.m801401200","title":"Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Glyceraldehyde 3-phosphate dehydrogenase; AP site; DNA-(apurinic or apyrimidinic site) lyase; AP endonuclease; DNA damage; Biology; Biochemistry; Dehydrogenase; DNA repair; DNA; Base excision repair; Gene knockdown; Molecular biology; Endonuclease; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003443136,0.0001787938,0.0003258368,0.0000208312,0.0001100557,0.000004145487,0.0003598277,0.0003558831,0.00002308297],"category_scores_gemma":[0.0002277694,0.0001097373,0.0003903617,0.0001490357,0.0002394925,0.000004730379,0.0001720487,0.0002972227,3.980433e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002972621,"about_ca_system_score_gemma":0.0000725553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009821131,"about_ca_topic_score_gemma":0.000002387295,"domain_scores_codex":[0.9986938,0.00006733515,0.0006286859,0.0002507473,0.0001252061,0.0002342783],"domain_scores_gemma":[0.9988649,0.00002410417,0.0005716897,0.000361005,0.00009872826,0.00007959956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024369,0.0001549948,0.005949821,0.000011078,0.00004444635,0.00001839557,0.00001434322,0.00001535078,0.9933623,0.00002438768,0.0002475603,0.00005485175],"study_design_scores_gemma":[0.000556213,0.0002010092,0.003678494,0.00003653054,0.00001122923,0.0003185584,0.00002827462,0.0000120627,0.9919313,0.0002590267,0.002829168,0.0001381937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973977,0.0006347214,0.00006220287,0.00008767009,0.00001391568,0.0001342101,0.00001224992,0.00001390357,0.001643377],"genre_scores_gemma":[0.9986086,0.0002259772,0.0007637144,0.0001543987,0.00009923948,0.00001942749,0.00002181531,0.00001214452,0.00009461746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581607,"threshold_uncertainty_score":0.4474959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379140942744393,"score_gpt":0.2521048853580002,"score_spread":0.2383134759305562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}