{"id":"W2018631567","doi":"10.1073/pnas.111382798","title":"Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Recombinant DNA; Fusion protein; Affinity chromatography; Biology; Transfection; HEK 293 cells; Molecular biology; Biochemistry; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003901451,0.00005074943,0.00007680522,0.00005417272,0.00008394587,0.000003328626,0.0001513684,0.00007846631,0.00001437067],"category_scores_gemma":[0.0002718082,0.00003103511,0.00003669293,0.0003337241,0.0004031939,0.00002027692,0.00006696903,0.00003841483,1.835939e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007364129,"about_ca_system_score_gemma":0.00002627915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002944023,"about_ca_topic_score_gemma":2.478717e-7,"domain_scores_codex":[0.9992554,0.000005631563,0.000226447,0.0001268612,0.0003318993,0.00005376877],"domain_scores_gemma":[0.9991558,0.00001237327,0.0003767344,0.000008964648,0.0004334944,0.00001259397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007021072,0.00003037949,0.01928358,0.00003905249,0.00001042922,7.131428e-10,0.00002427144,0.0003602457,0.9752724,0.001991044,0.0008004968,0.002117857],"study_design_scores_gemma":[0.000205988,0.0001140067,0.03921748,0.00008766409,0.000008640794,0.00002326219,0.00004019383,0.005755377,0.9508525,0.002828465,0.0008182205,0.00004822722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986268,0.0001341733,0.0000128878,0.0005291299,0.000131251,0.0001100051,0.00000515097,0.000001517216,0.0004490674],"genre_scores_gemma":[0.9993516,0.00008372419,0.0002330798,0.00004773632,0.00006024713,0.000001564659,7.807056e-7,0.000002179688,0.0002191248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02441996,"threshold_uncertainty_score":0.1485585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797889552491048,"score_gpt":0.2651504709290365,"score_spread":0.237171575404126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}