{"id":"W2018637944","doi":"10.1210/me.2007-0053","title":"Ikaros Is Regulated through Multiple Histone Modifications and Deoxyribonucleic Acid Methylation in the Pituitary","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Biology; DNA methylation; Chromatin remodeling; Epigenomics; Epigenetics; Epigenetics of physical exercise; Genetics; Chromatin; Histone; Cell biology; Cancer research; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810251,0.0001665655,0.0001441521,0.00009363275,0.0001098257,0.00001610273,0.0001942735,0.0001744846,0.000008312463],"category_scores_gemma":[0.0001230727,0.0001502885,0.00006100477,0.0001914735,0.0001478846,0.000007019801,0.0000810161,0.000154586,0.000006621153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002260144,"about_ca_system_score_gemma":0.00002402063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001264985,"about_ca_topic_score_gemma":0.000173866,"domain_scores_codex":[0.9986293,0.0001475685,0.0003081095,0.0004129759,0.0001326502,0.0003693525],"domain_scores_gemma":[0.9992712,0.00004200958,0.00008992778,0.0004873066,0.0000687088,0.00004080555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003902247,0.0000624391,0.002751735,0.000006301678,0.00002555276,0.00002511975,0.0003897872,0.00009124314,0.9903005,0.001773599,0.00006768462,0.00446705],"study_design_scores_gemma":[0.0007033405,0.0001508639,0.04880658,0.000003730508,0.00002459253,0.00003305421,0.0001581731,0.0002048683,0.9346348,0.002930516,0.01215811,0.0001913911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445153,0.007425135,0.04544463,0.0008278409,0.00008014416,0.000313132,0.000008241173,0.00001499721,0.001370596],"genre_scores_gemma":[0.9954759,0.0004780382,0.003030651,0.0007198883,0.00004746334,0.00003013432,0.0001324143,0.00002275856,0.00006274712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05566569,"threshold_uncertainty_score":0.6128587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815428880679335,"score_gpt":0.2963430220689634,"score_spread":0.2781887332621701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}