{"id":"W2018719108","doi":"10.1186/1471-2407-11-318","title":"Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101 - Breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI","year":2011,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research Institute","keywords":"Medicine; Breast cancer; Heart failure; Trastuzumab; Internal medicine; Cardiology; Ventricular remodeling; Placebo; Cardiotoxicity; Ejection fraction; Oncology; Randomized controlled trial; Cancer; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02400046,0.003932162,0.004117587,0.0009982022,0.001519989,0.002294389,0.002414821,0.004762727,0.0135672],"category_scores_gemma":[0.01632763,0.002298742,0.002263357,0.0007477254,0.004019583,0.001795366,0.0009898971,0.005058971,0.003624293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017869,"about_ca_system_score_gemma":0.005423251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004239452,"about_ca_topic_score_gemma":0.001125348,"domain_scores_codex":[0.9845206,0.01088615,0.000784719,0.001566713,0.001352903,0.0008889301],"domain_scores_gemma":[0.9947546,0.001855604,0.001131544,0.000526306,0.0005405047,0.001191528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9530807,0.01065844,0.002735301,0.003756976,0.001437629,0.0001963888,0.0002165069,0.0009338657,0.003124621,0.003554086,0.004062139,0.01624334],"study_design_scores_gemma":[0.9623041,0.02790017,0.00169405,0.000266954,0.0007371524,0.00004844249,0.00002790882,0.0009495447,0.0004320704,0.001327766,0.004273649,0.00003822622],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.09428794,0.004779191,0.00762623,0.004785072,0.003152678,0.875547,0.002756511,0.000279318,0.006786093],"genre_scores_gemma":[0.1310453,0.001334641,0.01560724,0.005610854,0.001113821,0.8410245,0.0008771514,0.00002995889,0.003356553],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02400046,"threshold_uncertainty_score":0.1269281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06515982059342969,"score_gpt":0.3277750967876751,"score_spread":0.2626152761942454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}