{"id":"W2018734015","doi":"10.1016/j.jpsychires.2012.08.017","title":"Peripheral brain-derived neurotrophic factor changes along treatment with extended release quetiapine during acute mood episodes: An open-label trial in drug-free patients with bipolar disorder","year":2012,"lang":"en","type":"article","venue":"Journal of Psychiatric Research","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Young Mania Rating Scale; Quetiapine; Clinical Global Impression; Bipolar disorder; Psychology; Mania; Mood; Brain-derived neurotrophic factor; Positive and Negative Syndrome Scale; Internal medicine; Biomarker; Psychiatry; Neurotrophic factors; Oncology; Medicine; Schizophrenia (object-oriented programming); Psychosis; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008260636,0.001441233,0.002725443,0.0004476742,0.0005052157,0.0008504742,0.0008251301,0.001386033,0.003407852],"category_scores_gemma":[0.001386675,0.0005052798,0.001432505,0.0004935365,0.001128452,0.001133204,0.0003223274,0.002825769,0.000557857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009059389,"about_ca_system_score_gemma":0.0006780605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002395656,"about_ca_topic_score_gemma":0.006330695,"domain_scores_codex":[0.9996052,0.0001436679,0.00003244859,0.00008157807,0.00003562128,0.0001015524],"domain_scores_gemma":[0.9992072,0.000209462,0.000130503,0.00006319494,0.00003716292,0.0003524408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9450539,0.01247214,0.002357919,0.0002667407,0.0007239534,0.0001427861,0.00012036,0.000383608,0.007723156,0.00006664774,0.0003433371,0.03034546],"study_design_scores_gemma":[0.7626428,0.2166831,0.01740577,0.0000332704,0.0005217346,0.0001587817,0.00007409811,0.0008398023,0.001089056,0.00008829834,0.0004230309,0.00004023132],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977398,0.0009229286,0.0001361326,0.0001149446,0.00008112138,0.0002950405,0.0002232471,0.00004073601,0.0004460693],"genre_scores_gemma":[0.9971335,0.0008708086,0.0004072882,0.0001217146,0.0001396,0.0003263823,0.0003599836,0.000009764608,0.0006309552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003407852,"threshold_uncertainty_score":0.01140046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04604488015594314,"score_gpt":0.3612213798694538,"score_spread":0.3151764997135106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}