{"id":"W2018742347","doi":"10.1124/jpet.102.046987","title":"Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":478,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Olanzapine; Quetiapine; Clozapine; Pharmacology; Dosing; Haloperidol; In vivo; Antipsychotic; Pharmacokinetics; Atypical antipsychotic; Risperidone; Medicine; Chemistry; Dopamine; Internal medicine; Schizophrenia (object-oriented programming); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007333192,0.0009841659,0.002275977,0.0003854476,0.0007724705,0.001947808,0.001376092,0.001554214,0.001447625],"category_scores_gemma":[0.01040783,0.000490382,0.0007408504,0.000467001,0.002247224,0.002012142,0.0008787698,0.003114151,0.0005314702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001116836,"about_ca_system_score_gemma":0.001487483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009204693,"about_ca_topic_score_gemma":0.003385602,"domain_scores_codex":[0.9956902,0.002350513,0.0004128083,0.0006217018,0.0007451661,0.0001796743],"domain_scores_gemma":[0.9927747,0.002866703,0.001850339,0.001487354,0.0008018374,0.0002190768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009493405,0.001356484,0.0193408,0.001402307,0.0008386746,0.001494022,0.0006128693,0.003623091,0.6301216,0.02052536,0.01173629,0.2994552],"study_design_scores_gemma":[0.0008014072,0.02347409,0.0466628,0.0006300995,0.001174932,0.008600526,0.001011399,0.02697379,0.7937478,0.03608019,0.06045366,0.0003893338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5526295,0.02514341,0.3578254,0.03855075,0.004552431,0.0007947924,0.001207214,0.003525933,0.0157706],"genre_scores_gemma":[0.9289588,0.006437057,0.05479519,0.004311983,0.0008521613,0.0002281415,0.0004022491,0.0003939317,0.003620589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007333192,"threshold_uncertainty_score":0.03878206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1741803341127328,"score_gpt":0.4776693625642115,"score_spread":0.3034890284514787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}