{"id":"W2018746851","doi":"10.1002/glia.21157","title":"Proton pump inhibitors reduce interferon‐γ‐induced neurotoxicity and STAT3 phosphorylation of human astrocytes","year":2011,"lang":"en","type":"article","venue":"Glia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Neurotoxicity; STAT protein; STAT1; Biology; Neuroinflammation; Phosphorylation; STAT3; Signal transduction; Pharmacology; Cancer research; Immunology; Cell biology; Medicine; Inflammation; Internal medicine; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009168602,0.0001501368,0.0001451175,0.0001020079,0.0001373495,0.00002844521,0.0001595747,0.0000550437,0.0001232935],"category_scores_gemma":[0.0001668745,0.0001493518,0.00004656778,0.0001879943,0.00006665201,0.0002733395,0.0001034497,0.0001495222,0.00001437133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001562927,"about_ca_system_score_gemma":0.00002564688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001223664,"about_ca_topic_score_gemma":0.000005541521,"domain_scores_codex":[0.9986862,0.0001530723,0.0003471086,0.0003982741,0.0002459979,0.0001693566],"domain_scores_gemma":[0.9993492,0.00001875538,0.0002364548,0.000261487,0.0000456447,0.00008842956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000052487,0.00005690879,0.000438701,0.0000252443,7.332885e-7,0.000002611406,0.0003957336,0.000001277506,0.9964143,0.002272805,0.00002471839,0.0003144478],"study_design_scores_gemma":[0.0003681351,0.0003964325,0.003284606,0.00002214333,0.000004497573,0.000007326429,0.00001210728,0.00014688,0.9952235,0.00037392,0.00004249708,0.000117925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977183,0.000001332242,0.00008614339,0.000031612,0.0003623245,0.0008206912,0.000007147828,0.00009126583,0.0008812189],"genre_scores_gemma":[0.9993989,0.00000329595,0.0001181758,0.0001421127,0.00003262963,0.0000447247,0.000001004395,0.00002070738,0.0002384323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845905,"threshold_uncertainty_score":0.6090388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08265197285498554,"score_gpt":0.2821416692118389,"score_spread":0.1994896963568533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}