{"id":"W2018748658","doi":"10.1021/bi9925569","title":"Deimination of Myelin Basic Protein. 1. Effect of Deimination of Arginyl Residues of Myelin Basic Protein on Its Structure and Susceptibility to Digestion by Cathepsin D","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Hospital for Sick Children","funders":"","keywords":"Citrullination; Myelin basic protein; Citrulline; Chemistry; Biochemistry; Cathepsin D; Peptide; Cathepsin; Digestion (alchemy); Arginine; Cathepsin L; Molecular biology; Enzyme; Myelin; Biology; Chromatography; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00037823,0.0002299835,0.0003167741,0.00005324702,0.00003164286,0.000005322333,0.0001624199,0.0003418085,0.00004723248],"category_scores_gemma":[0.0003904994,0.0002143532,0.00008913887,0.0001382149,0.0001044971,0.000009570422,0.00004744951,0.00009952621,7.962184e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002817803,"about_ca_system_score_gemma":0.0000777116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004028254,"about_ca_topic_score_gemma":0.000006614258,"domain_scores_codex":[0.9985117,0.0001236157,0.0004681957,0.0004461933,0.0002803197,0.0001699767],"domain_scores_gemma":[0.9989197,0.00002107053,0.0003188999,0.0004353226,0.0002290467,0.00007599917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008326384,0.0001273731,0.0002553986,0.0009302807,0.00002389987,3.338367e-7,0.00004925221,0.00001141767,0.9895325,0.0000138259,0.00009245571,0.00813058],"study_design_scores_gemma":[0.0006792091,0.001637054,0.0006790134,0.0003554749,0.00003439049,0.000002178194,0.00002090561,0.00002940639,0.9962735,0.00007723139,0.00003786079,0.0001737531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978809,0.0005542109,0.00006952127,0.00006175297,0.00001840212,0.001010216,0.0003164115,0.000007940323,0.000080666],"genre_scores_gemma":[0.998929,0.00002352873,0.0003805197,0.00001016979,0.00006653686,0.00005777491,0.0002819944,0.00002071216,0.0002298227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007956827,"threshold_uncertainty_score":0.8741069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004755492784327561,"score_gpt":0.2285073771659508,"score_spread":0.2237518843816233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}