{"id":"W2018750966","doi":"10.1016/j.copbio.2013.03.008","title":"Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks","year":2013,"lang":"en","type":"review","venue":"Current Opinion in Biotechnology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Novo Nordisk Fonden; European Research Council; Knut och Alice Wallenbergs Stiftelse; Fondation Chalmers; VINNOVA","keywords":"Metabolic engineering; Biochemical engineering; Adipic acid; Synthetic biology; Production (economics); Sustainable production; Chemical industry; Computer science; Biotechnology; Chemistry; Engineering; Computational biology; Biology; Biochemistry; Environmental engineering; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001344477,0.001497641,0.001998988,0.002104871,0.0003000649,0.001763274,0.001736104,0.001891087,0.004365223],"category_scores_gemma":[0.001198927,0.0005084879,0.0006806228,0.003607024,0.0009037098,0.002966612,0.001456461,0.003258702,0.003458702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063917,"about_ca_system_score_gemma":0.001685479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185188,"about_ca_topic_score_gemma":0.00244573,"domain_scores_codex":[0.9996031,0.00003986937,0.00003629794,0.00007405472,0.0001939931,0.00005268722],"domain_scores_gemma":[0.9993517,0.0002405293,0.0001020369,0.00002567695,0.0001961867,0.00008385596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008362416,0.00007848215,0.0001190635,0.01455269,0.00006618788,0.0001943213,0.00002889483,0.0004929539,0.00891961,0.00619682,0.02510901,0.9441583],"study_design_scores_gemma":[0.00001979005,0.00008228369,0.0003541766,0.00149454,0.00008128823,0.0005782385,0.00003708438,0.000177027,0.002133839,0.002534408,0.992476,0.00003125043],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001417502,0.996723,0.0008181845,0.0005146378,0.000407212,0.00000629299,0.00002822045,0.00001626482,0.001344518],"genre_scores_gemma":[0.000587526,0.9978518,0.0005879506,0.0002109835,0.0001925357,0.000004678605,0.00004689387,0.000002514033,0.0005150961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004365223,"threshold_uncertainty_score":0.01460314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867148121327795,"score_gpt":0.2987447285666552,"score_spread":0.2800732473533773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}