{"id":"W2018785940","doi":"10.1371/journal.pone.0044260","title":"Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Eisai; King's College London; National Institute for Health and Care Research; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Bayer HealthCare; European Commission; Alzheimer's Disease Neuroimaging Initiative; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amorfix Life Sciences; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Neuroimaging; Alzheimer's disease; Medicine; Cerebral amyloid angiopathy; Amyloid (mycology); Cognitive decline; Internal medicine; Disease; Pathology; Psychology; Dementia; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113644,0.0005248334,0.0005443318,0.001109654,0.0001788947,0.0009084498,0.0002909406,0.0005744452,0.001343408],"category_scores_gemma":[0.002955257,0.0002034037,0.0001948679,0.0006247111,0.0002812851,0.0002591597,0.0003058964,0.0006198582,0.0005331092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936014,"about_ca_system_score_gemma":0.000210657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159909,"about_ca_topic_score_gemma":0.001511029,"domain_scores_codex":[0.9994005,0.0002394516,0.00006352678,0.0001014404,0.0001594517,0.00003565423],"domain_scores_gemma":[0.9988311,0.0005812158,0.0002958245,0.00008922333,0.0001523252,0.00005041017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003980546,0.0004526731,0.7989974,0.0003091031,0.0005591113,0.00107484,0.0002418667,0.007608923,0.12372,0.0005270888,0.001585705,0.06094287],"study_design_scores_gemma":[0.0001185483,0.001141531,0.9216473,0.00006833115,0.0002846874,0.003538823,0.0001138637,0.01849719,0.05100723,0.001208805,0.002326872,0.00004680307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979597,0.001894151,0.0124794,0.0001787003,0.00002085224,0.0001221742,0.002695023,0.0001612927,0.002851368],"genre_scores_gemma":[0.9810915,0.0008293957,0.01511382,0.00009824638,0.00002064801,0.0001320135,0.001707191,0.00001885178,0.0009882959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001343408,"threshold_uncertainty_score":0.005889535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05104412530141166,"score_gpt":0.2873813408628914,"score_spread":0.2363372155614797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}