{"id":"W2018796139","doi":"10.1016/j.ccr.2009.12.050","title":"A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Argonne National Laboratory; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society; Chemotherapy Foundation; Samuel Waxman Cancer Research Foundation; Ontario Ministry of Health and Long-Term Care; University of Maryland Foundation","keywords":"BCL6; In vivo; Corepressor; Lymphoma; In vitro; Cancer research; Diffuse large B-cell lymphoma; Biology; Oncogene; Cell culture; Xenotransplantation; Molecular biology; Chemistry; Repressor; Cell; B cell; Gene; Transplantation; Cell cycle; Gene expression; Biochemistry; Immunology; Germinal center; Genetics; Medicine; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000185832,0.0003927452,0.0004736929,0.0003562856,0.0002594829,0.0003883912,0.0002935936,0.0003175272,0.001856189],"category_scores_gemma":[0.0001113203,0.0001605339,0.0002370813,0.0002691428,0.0001832042,0.0002399759,0.0001335889,0.0009096079,0.0005916128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003505799,"about_ca_system_score_gemma":0.000252116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007989069,"about_ca_topic_score_gemma":0.001555406,"domain_scores_codex":[0.9998885,0.00001965261,0.00000721583,0.00001332891,0.00003266484,0.00003859474],"domain_scores_gemma":[0.9999074,0.00003176782,0.00001225675,0.00001306572,0.000008705535,0.00002685924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007612972,0.00032021,0.0002236972,0.0001146567,0.00002439157,0.00007052034,0.00002324279,0.0003327914,0.9895362,0.0002080092,0.0003932647,0.007991727],"study_design_scores_gemma":[0.0001467291,0.001204761,0.001243398,0.000003735798,0.00002085987,0.0002926744,0.00001529695,0.001020111,0.9926562,0.00005469794,0.003336577,0.000005001974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793752,0.009769044,0.004984094,0.0004487929,0.000163889,0.00007838415,0.0006886244,0.0003556167,0.004136361],"genre_scores_gemma":[0.9903656,0.003254378,0.002119016,0.00006774477,0.00002830833,0.00003427354,0.00078619,0.00002460965,0.003319738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001856189,"threshold_uncertainty_score":0.006209552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008186205628108284,"score_gpt":0.2214856505327747,"score_spread":0.2132994449046664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}