{"id":"W2018810533","doi":"10.3816/cbc.2008.n.049","title":"Extended Adjuvant Endocrine Therapy in Breast Cancer: Current Status and Future Directions","year":2008,"lang":"en","type":"review","venue":"Clinical Breast Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; University of Toronto; McMaster University","funders":"","keywords":"Letrozole; Medicine; Tamoxifen; Breast cancer; Aromatase inhibitor; Oncology; Interim analysis; Anastrozole; Adjuvant therapy; Internal medicine; Exemestane; Adjuvant; Clinical trial; Randomized controlled trial; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001323805,0.0005730398,0.00139543,0.00009893731,0.0001028054,0.00002334992,0.00022353,0.0006772068,0.0001003666],"category_scores_gemma":[0.00001342823,0.0004137199,0.0006263437,0.0002835182,0.0002610724,0.000006200011,0.0001480966,0.001089511,0.00001037634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009967427,"about_ca_system_score_gemma":0.0009776347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002450229,"about_ca_topic_score_gemma":0.00006251363,"domain_scores_codex":[0.997084,0.0003659669,0.0008526841,0.0009526181,0.0001640547,0.0005806306],"domain_scores_gemma":[0.9986715,0.00006553698,0.0003377553,0.0004649168,0.00009968438,0.0003605461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001315236,0.0002979557,0.00249761,0.0004878849,0.0003346112,0.00002096841,0.000007633443,4.194605e-7,0.000007605418,0.000004336325,0.001894734,0.9943147],"study_design_scores_gemma":[0.00119787,0.0001152819,0.02013082,0.001786857,0.0001893518,0.0006322624,0.00000386509,0.00000192597,0.000003520602,0.000003292094,0.9754617,0.0004732615],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002877994,0.9926825,5.35968e-7,0.0003178795,0.00220328,0.0006682617,0.001167991,0.0000264256,0.0000551535],"genre_scores_gemma":[0.0002325696,0.9946047,0.00001037047,0.0001083267,0.004087176,0.0004541866,0.0003036077,0.00008342398,0.000115627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938415,"threshold_uncertainty_score":0.9998314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0269639738199417,"score_gpt":0.3900944497162928,"score_spread":0.3631304758963511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}