{"id":"W2018815288","doi":"10.1089/hum.2008.208","title":"Strong Muscle-Specific Regulatory Cassettes Based on Multiple Copies of the Human Slow Troponin I Gene Upstream Enhancer","year":2009,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Biotechnology Research Institute; National Research Council Canada","funders":"","keywords":"Enhancer; Gene; Biology; Regulatory sequence; Computational biology; Genetics; Regulation of gene expression; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000502117,0.00095567,0.0004183277,0.0003933192,0.0001443761,0.0003083789,0.0006239265,0.0004175748,0.00168727],"category_scores_gemma":[0.0002962905,0.000410054,0.0004970396,0.0002319437,0.0004305778,0.0002671864,0.0007239811,0.0009383914,0.000676272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003063578,"about_ca_system_score_gemma":0.0002690663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002527081,"about_ca_topic_score_gemma":0.0006320984,"domain_scores_codex":[0.9995537,0.00005146831,0.00005846447,0.0001134582,0.0001589821,0.00006381878],"domain_scores_gemma":[0.9996608,0.0001015567,0.0001052439,0.00004293947,0.00002406674,0.00006540397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003054428,0.00001727402,0.00007114936,0.00002224716,0.000002977199,0.00001996814,0.000006968653,0.0000386849,0.9990865,0.00004997578,0.00001102705,0.0006427748],"study_design_scores_gemma":[0.00004336591,0.0004380848,0.002268516,0.0000125507,0.00003083772,0.0003346561,0.00001317213,0.0007651417,0.9934815,0.00003744365,0.00256674,0.000008092539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729276,0.001096522,0.02324041,0.00007557782,0.00005679296,0.000244365,0.0004548386,0.0003840252,0.001519885],"genre_scores_gemma":[0.9560412,0.0009180489,0.03336104,0.00009848944,0.00003078095,0.000252894,0.002171336,0.0001926179,0.006933634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168727,"threshold_uncertainty_score":0.005644441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03450447745596588,"score_gpt":0.2825726355627339,"score_spread":0.248068158106768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}