{"id":"W2018823145","doi":"10.1016/j.bpj.2014.11.711","title":"PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding and Ca2+ Signaling, which Requires Ser332/334 in the CaM-Binding C Terminus","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Microglia; Calmodulin; Protein kinase A; Cell biology; HEK 293 cells; Kinase; Phosphorylation; Chemistry; Gating; Mutant; Signal transduction; Biology; Biophysics; Biochemistry; Receptor; Enzyme; Gene; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808758,0.0004094154,0.0003502876,0.000180113,0.0002171971,0.0003729511,0.0002755722,0.000426774,0.006604666],"category_scores_gemma":[0.0003376588,0.0002154792,0.0004389874,0.0001221385,0.0005062063,0.000273513,0.0001774408,0.001280642,0.001247913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004097172,"about_ca_system_score_gemma":0.0005613409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357786,"about_ca_topic_score_gemma":0.002361172,"domain_scores_codex":[0.9998591,0.00001516947,0.00001580046,0.00002752994,0.00003265703,0.00004962039],"domain_scores_gemma":[0.9998537,0.00002692432,0.00001789277,0.00002692946,0.00001256169,0.0000620171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007520732,0.00007159096,0.0001109507,0.0000442959,0.00001371295,0.0000828519,0.00001599953,0.00006758983,0.9968072,0.0002369105,0.0002497083,0.001547168],"study_design_scores_gemma":[0.0001484748,0.000463703,0.006164102,0.000009239803,0.00003872232,0.001020071,0.000044333,0.0008064716,0.9871435,0.0001979225,0.003954348,0.000009094453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876447,0.002286074,0.002690464,0.0009174066,0.0002773221,0.00005897456,0.001472664,0.0002199713,0.00443243],"genre_scores_gemma":[0.9892917,0.001027375,0.001316086,0.0003004172,0.0000521419,0.00005250701,0.001263892,0.00007616998,0.006619689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006604666,"threshold_uncertainty_score":0.02209485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03820754920108428,"score_gpt":0.3035739261854484,"score_spread":0.2653663769843642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}