{"id":"W2018823145","doi":"10.1016/j.bpj.2014.11.711","title":"PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding and Ca2+ Signaling, which Requires Ser332/334 in the CaM-Binding C Terminus","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Microglia; Calmodulin; Protein kinase A; Cell biology; HEK 293 cells; Kinase; Phosphorylation; Chemistry; Gating; Mutant; Signal transduction; Biology; Biophysics; Biochemistry; Receptor; Enzyme; Gene; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004705056,0.0001309559,0.0001122341,0.00005259427,0.0003326354,0.0001812902,0.0001396733,0.00007943055,0.000003743614],"category_scores_gemma":[0.00007098787,0.00007655883,0.00004394344,0.0001279626,0.0001106736,0.00001837087,0.00006700726,0.0002451434,0.000002604945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002002006,"about_ca_system_score_gemma":0.00004916544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001109762,"about_ca_topic_score_gemma":0.00001151416,"domain_scores_codex":[0.9990562,0.0001622611,0.0001985224,0.0001930529,0.0001935137,0.0001964092],"domain_scores_gemma":[0.9995598,0.00002245263,0.0001215595,0.0001115386,0.00008296159,0.0001017011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005133717,0.00004830325,0.001647429,0.000007380312,0.00001633352,0.000005057205,0.000673455,0.00002512174,0.9917256,0.0001112123,0.002730954,0.002957843],"study_design_scores_gemma":[0.00399837,0.00153562,0.009787736,0.0002817562,0.0001337282,0.001456892,0.007171001,0.001549424,0.9155585,0.0007849382,0.05677683,0.0009651572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982272,0.0002821755,0.00004060991,0.0007014011,0.0005148306,0.00009876885,0.000003762507,0.000004622495,0.0001266202],"genre_scores_gemma":[0.9979265,0.00009108324,0.00001474048,0.00007155591,0.001718585,0.000005628404,0.00002080535,0.00001038141,0.0001406587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07616702,"threshold_uncertainty_score":0.3121979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03820754920108428,"score_gpt":0.3035739261854484,"score_spread":0.2653663769843642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}