{"id":"W2018835655","doi":"10.1021/ja043782v","title":"Enantioselective Tandem Michael Addition/H<sub>2</sub>-Hydrogenation Catalyzed by Ruthenium Hydride Borohydride Complexes Containing β-aminophosphine Ligands","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Ruthenium; Enantioselective synthesis; Diastereomer; Ligand (biochemistry); Catalysis; BINAP; Borohydride; Michael reaction; Medicinal chemistry; Tandem; Hydride; Combinatorial chemistry; Organic chemistry; Metal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003513547,0.0003315512,0.0006703745,0.00006109741,0.0002819787,0.00006115856,0.0006470889,0.000142332,0.00005147418],"category_scores_gemma":[0.0003572721,0.0002524399,0.00104007,0.001211828,0.0004878364,0.000228359,0.0001341885,0.0007140376,0.000009141011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009774795,"about_ca_system_score_gemma":0.0002217498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008962952,"about_ca_topic_score_gemma":0.00000420109,"domain_scores_codex":[0.9974802,0.0000258714,0.0008404301,0.0003250216,0.0008931594,0.0004353242],"domain_scores_gemma":[0.9970253,0.0002413498,0.001795468,0.0003147307,0.0003813788,0.0002417948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006551991,0.0002014495,0.0005540961,0.00001300005,0.0005412636,0.000004082096,0.0006315976,0.0001121429,0.9931287,0.00001820022,0.003201496,0.001528519],"study_design_scores_gemma":[0.001615736,0.00004375355,0.0001380732,0.00006170265,0.0002454937,0.0001108937,0.0008778049,0.0002861769,0.9949636,0.0004409002,0.0009107709,0.0003051198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996543,0.0004076668,0.001090344,0.001477875,0.00007594183,0.00007157625,0.0001102568,0.00005318615,0.0001701814],"genre_scores_gemma":[0.9978537,0.0002805921,0.0003729983,0.0009329763,0.0003505453,0.00001076997,0.0001216282,0.0000471294,0.00002966822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002290725,"threshold_uncertainty_score":0.9999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005518209042365234,"score_gpt":0.2181809099094342,"score_spread":0.2126627008670689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}