{"id":"W2018837575","doi":"10.1002/prot.22661","title":"UV and X‐ray structural studies of a 101‐residue long Tat protein from a HIV‐1 primary isolate and of its mutated, detoxified, vaccine candidate","year":2009,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Small-angle X-ray scattering; Circular dichroism; Transactivation; Mutant; Chemistry; Human immunodeficiency virus (HIV); Residue (chemistry); Protein secondary structure; Fluorescence; In vitro; Size-exclusion chromatography; Crystallography; Biophysics; Biochemistry; Biology; Scattering; Virology; Enzyme; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699103,0.0002392442,0.0001936673,0.0001162151,0.0002823486,0.0001799854,0.0002157893,0.0003419642,0.0005955853],"category_scores_gemma":[0.0002917222,0.0001191935,0.0003322902,0.0003112745,0.0002490228,0.0001783488,0.0001283896,0.0006702799,0.0001659941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368063,"about_ca_system_score_gemma":0.0001928826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009016623,"about_ca_topic_score_gemma":0.0006471411,"domain_scores_codex":[0.9999056,0.0000191389,0.000006056153,0.0000188719,0.00003476275,0.00001549256],"domain_scores_gemma":[0.9998122,0.00006050787,0.00004904911,0.00001616758,0.00002955492,0.00003250839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000269775,0.00008806194,0.001180934,0.00006584718,0.00001681376,0.0002443847,0.0001575773,0.001017658,0.9952354,0.0003039428,0.00008793563,0.001331627],"study_design_scores_gemma":[0.0000322867,0.0004642518,0.02203967,0.00001443276,0.00004394037,0.001553609,0.0002283884,0.005557866,0.9666243,0.0001378032,0.003285188,0.00001844387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982102,0.000380765,0.0008172081,0.00003701865,0.00000608757,0.00000523607,0.00016274,0.000005969108,0.0003748891],"genre_scores_gemma":[0.9938936,0.0004995168,0.002880475,0.0000456158,0.000005409089,0.00001479329,0.001355071,0.00001418417,0.001291154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009016623,"threshold_uncertainty_score":0.002443731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009150505279904703,"score_gpt":0.235142321255572,"score_spread":0.2259918159756673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}