{"id":"W2018837575","doi":"10.1002/prot.22661","title":"UV and X‐ray structural studies of a 101‐residue long Tat protein from a HIV‐1 primary isolate and of its mutated, detoxified, vaccine candidate","year":2009,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Small-angle X-ray scattering; Circular dichroism; Transactivation; Mutant; Chemistry; Human immunodeficiency virus (HIV); Residue (chemistry); Protein secondary structure; Fluorescence; In vitro; Size-exclusion chromatography; Crystallography; Biophysics; Biochemistry; Biology; Scattering; Virology; Enzyme; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024984,0.0002519004,0.0004704904,0.0001532946,0.0001828306,0.0000239417,0.00006699844,0.0001813934,0.00007542883],"category_scores_gemma":[0.00006360729,0.0001680296,0.00003544548,0.0001256551,0.0001787503,0.0002376591,0.00008710927,0.0002311274,0.000004628062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002488806,"about_ca_system_score_gemma":0.00005085496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006651278,"about_ca_topic_score_gemma":0.0001190502,"domain_scores_codex":[0.9989048,0.00007179315,0.0004785896,0.0001930622,0.0000824839,0.0002692308],"domain_scores_gemma":[0.9993089,0.00004469508,0.0002774131,0.0001647983,0.0001450196,0.00005913934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004433089,0.00008719698,0.01702576,0.001916101,0.001758999,0.00001429242,0.005542157,0.00001255967,0.8332512,0.0003623076,0.0002814561,0.1353148],"study_design_scores_gemma":[0.01619934,0.005482554,0.513344,0.0007289894,0.0005248096,0.0002815533,0.002569267,0.0005461942,0.4552419,0.003726556,0.0005603045,0.0007944978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869362,0.01056144,0.0003739662,0.0002033029,0.00006411135,0.001142051,0.0006460119,0.00002703797,0.00004588405],"genre_scores_gemma":[0.9964185,0.0006032978,0.002391508,0.00006124056,0.00001516476,0.00001580038,0.0003111965,0.00000748397,0.0001757657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4963183,"threshold_uncertainty_score":0.6852047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009150505279904703,"score_gpt":0.235142321255572,"score_spread":0.2259918159756673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}