{"id":"W2018857756","doi":"10.1182/blood-2003-10-3550","title":"NUP98-Topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Fusion gene; Biology; Haematopoiesis; Cancer research; Molecular biology; Myeloid; Bone marrow; Stem cell; Gene; Cell biology; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006686,0.0003694956,0.0001628589,0.0001823292,0.0001117913,0.0002471336,0.0001458559,0.0001846821,0.000721971],"category_scores_gemma":[0.00008442204,0.00009435962,0.0001475374,0.0001783378,0.0001901232,0.0001150846,0.0002132675,0.0003697974,0.0002558673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948635,"about_ca_system_score_gemma":0.0001048335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001574155,"about_ca_topic_score_gemma":0.0002422349,"domain_scores_codex":[0.9998658,0.0000178529,0.00001427189,0.00003142711,0.00004351035,0.00002709698],"domain_scores_gemma":[0.9999194,0.00001349924,0.00002722585,0.00001379529,0.000004105051,0.00002204207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002911371,0.00001151519,0.00009995005,0.000009091598,0.000001867829,0.00003319093,0.000004858341,0.00002565285,0.9989271,0.00008941215,0.00001125517,0.0007570096],"study_design_scores_gemma":[0.000009431568,0.000219972,0.001924132,0.000002251792,0.00001055953,0.0006236469,0.00000750256,0.000542483,0.9935997,0.00003070601,0.003027787,0.00000178072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939367,0.000958328,0.003235077,0.0000487738,0.00001550642,0.00002762069,0.0002766388,0.0001487614,0.001352617],"genre_scores_gemma":[0.9957361,0.0003990548,0.001768421,0.00001101196,0.000005582045,0.00002275632,0.0005067551,0.000011588,0.001538738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000721971,"threshold_uncertainty_score":0.00241518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00865423393322618,"score_gpt":0.2175309949577992,"score_spread":0.208876761024573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}