{"id":"W2018858574","doi":"10.1111/j.1471-4159.2005.03050.x","title":"Up‐regulation of interleukin‐6 induced by prostaglandin E<sub>2</sub> from invading macrophages following nerve injury: an <i>in vivo</i> and <i>in vitro</i> study","year":2005,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Health Research","keywords":"Calphostin; Autocrine signalling; Sciatic nerve; Prostaglandin E2; Receptor antagonist; Prostaglandin E; Nerve injury; Receptor; Macrophage inflammatory protein; Cytokine; Prostaglandin E2 receptor; Colocalization; Macrophage; Peripheral nerve injury; Chemokine; Cell biology; Internal medicine; Endocrinology; Chemistry; Protein kinase A; Biology; Medicine; Antagonist; Kinase; In vitro; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405129,0.0005416545,0.0004861768,0.0002846072,0.0001873694,0.0002907094,0.0001486908,0.0003449069,0.001388935],"category_scores_gemma":[0.0001046541,0.000156038,0.0005296208,0.000174784,0.0003576241,0.0003701258,0.0001856942,0.000790642,0.000448215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425925,"about_ca_system_score_gemma":0.0001486559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000138678,"about_ca_topic_score_gemma":0.000267139,"domain_scores_codex":[0.999827,0.00004007384,0.00002023047,0.00002548786,0.00003032089,0.000056972],"domain_scores_gemma":[0.9998684,0.00003061588,0.00002782575,0.00001528264,0.00002184753,0.00003608637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000486902,0.0001297536,0.0001348375,0.0001286039,0.000004154887,0.0001052128,0.00003456407,0.00002080989,0.9980655,0.00003002783,0.00001841147,0.000841142],"study_design_scores_gemma":[0.00008487581,0.003469663,0.00734712,0.00001640847,0.00005756803,0.0005314924,0.0001090208,0.0005977283,0.9863446,0.00006609182,0.00136687,0.000008601674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910845,0.004117021,0.002983446,0.0001270367,0.0000913054,0.00006047881,0.0001806956,0.00003356421,0.001321961],"genre_scores_gemma":[0.986182,0.004648657,0.004967602,0.000180738,0.0001843346,0.0001827744,0.0004322563,0.00001755118,0.003204009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388935,"threshold_uncertainty_score":0.00464648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192361999955467,"score_gpt":0.2654654017365173,"score_spread":0.2535417817369627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}