{"id":"W2018858574","doi":"10.1111/j.1471-4159.2005.03050.x","title":"Up‐regulation of interleukin‐6 induced by prostaglandin E<sub>2</sub> from invading macrophages following nerve injury: an <i>in vivo</i> and <i>in vitro</i> study","year":2005,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Health Research","keywords":"Calphostin; Autocrine signalling; Sciatic nerve; Prostaglandin E2; Receptor antagonist; Prostaglandin E; Nerve injury; Receptor; Macrophage inflammatory protein; Cytokine; Prostaglandin E2 receptor; Colocalization; Macrophage; Peripheral nerve injury; Chemokine; Cell biology; Internal medicine; Endocrinology; Chemistry; Protein kinase A; Biology; Medicine; Antagonist; Kinase; In vitro; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082301,0.0001865467,0.0004920771,0.0001329533,0.00002704179,0.00002472836,0.00008963352,0.0000943633,0.000005569065],"category_scores_gemma":[0.00007718553,0.000166418,0.00009063236,0.000159713,0.00001476625,0.0002315022,0.00003840115,0.0003293069,3.000677e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113528,"about_ca_system_score_gemma":0.00005523521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002388955,"about_ca_topic_score_gemma":0.000009430862,"domain_scores_codex":[0.9985589,0.0000758548,0.0006390014,0.0002308696,0.0003108535,0.0001845521],"domain_scores_gemma":[0.9992057,0.00006303792,0.0003798923,0.0001636053,0.00004730418,0.0001404384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008938746,0.0007208469,0.02655909,0.00002989729,0.0000626722,0.0002286044,0.000512768,0.000002735306,0.9685295,1.056133e-7,0.0000368632,0.002423021],"study_design_scores_gemma":[0.004893855,0.0005982781,0.02296213,0.000256118,0.0001018429,0.00005619687,0.0004706025,0.0001404532,0.9703764,0.00003126814,0.000007868975,0.00010495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993715,0.000178049,0.00001019078,0.00009013378,0.0000870424,0.0002142181,0.00001771233,0.000007024189,0.00002412352],"genre_scores_gemma":[0.9994901,0.0000234961,0.0002262489,0.00009901895,0.0001084406,0.000004907626,0.00001095376,0.00002390622,0.00001288959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00399998,"threshold_uncertainty_score":0.6786328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192361999955467,"score_gpt":0.2654654017365173,"score_spread":0.2535417817369627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}