{"id":"W2018877915","doi":"10.1515/hmbci.2010.036","title":"Target deletion of the bifunctional type 12 17β-hydroxysteroid dehydrogenase in mice results in reduction of androgen and estrogen levels in heterozygotes and embryonic lethality in homozygotes","year":2010,"lang":"en","type":"article","venue":"Hormone Molecular Biology and Clinical Investigation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; F. Hoffmann-La Roche","keywords":"Biology; Hydroxysteroid dehydrogenase; Enzyme; Phosphofructokinase 2; Estrogen; Biochemistry; Estrone; Dehydrogenase; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001129767,0.000108028,0.0003277206,0.0001737746,0.00002028921,0.000003462582,0.000035573,0.0003290289,0.000001149056],"category_scores_gemma":[0.0008278611,0.00008550408,0.0000360919,0.000261366,0.0005254837,0.00005917585,0.00004403483,0.0003600436,2.63076e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001643344,"about_ca_system_score_gemma":0.0000885921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003764289,"about_ca_topic_score_gemma":0.0006358494,"domain_scores_codex":[0.9984688,0.0003340217,0.000689622,0.0002962693,0.00008986728,0.0001213765],"domain_scores_gemma":[0.9994101,0.0001464267,0.0001826995,0.0001312229,0.00006195088,0.00006758936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004630295,0.0000928347,0.3897773,0.00001619364,0.00001126637,0.000005930788,0.00009521162,0.00002469067,0.6080195,0.000378301,0.000002644222,0.001113143],"study_design_scores_gemma":[0.002628992,0.0003900506,0.9320362,0.00007269007,0.00002138064,0.00007480002,0.00003891678,0.003049207,0.056772,0.004809207,0.00002816568,0.00007845112],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964105,0.001556373,0.00001889843,0.001636453,0.00005378605,0.0002992396,0.000009037263,0.000003984966,0.00001169678],"genre_scores_gemma":[0.9989272,0.0002902693,0.0005789622,0.0001162605,0.0000172794,0.000005999301,0.00005362236,0.00000623161,0.00000421806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5512475,"threshold_uncertainty_score":0.3486755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610582397536369,"score_gpt":0.323400862200324,"score_spread":0.2872950382249603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}