{"id":"W2018899393","doi":"10.1007/s12672-011-0096-0","title":"Beyond Castration—Defining Future Directions in the Hormonal Treatment of Prostate Cancer","year":2011,"lang":"en","type":"review","venue":"Hormones and Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Prostate cancer; Cancer; Testosterone (patch); Abiraterone acetate; Androgen; Castration; Enzalutamide; Medicine; Intracrine; Abiraterone; Internal medicine; Prostate; Oncology; Androgen deprivation therapy; Cancer research; Hormone; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009501457,0.0003233734,0.000950879,0.0001657844,0.0001108536,0.00002322981,0.00007325144,0.0001665698,0.0001285878],"category_scores_gemma":[0.000002249156,0.0001618075,0.0002223533,0.0003881253,0.0001197842,0.0000554518,0.00001831099,0.0002137524,0.000003309748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264343,"about_ca_system_score_gemma":0.0007365608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00206101,"about_ca_topic_score_gemma":0.0008134327,"domain_scores_codex":[0.998744,0.00006810511,0.0003708242,0.0003233469,0.0002035789,0.0002901593],"domain_scores_gemma":[0.9994042,0.00004741097,0.0001724439,0.0002221812,0.00007233807,0.00008143971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001069716,0.0001679913,0.0006963749,0.001998072,0.0003143038,0.00003562776,0.002223671,1.272754e-7,0.000001534561,0.000188678,0.0004458341,0.9938208],"study_design_scores_gemma":[0.0008943548,0.0005681572,0.002306607,0.002017686,0.001142139,0.00005736529,0.0003938564,0.000001310109,0.000005709535,0.00003075352,0.9924233,0.0001587773],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001184051,0.9948854,9.425956e-8,0.0003543766,0.0001951679,0.001317394,0.0004329778,0.00001149973,0.001618973],"genre_scores_gemma":[0.0003147978,0.995024,0.00001995724,0.00002431181,0.000412004,0.002407686,0.0001683007,0.00003133563,0.001597653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936621,"threshold_uncertainty_score":0.6598319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06339424091530371,"score_gpt":0.3743805644422678,"score_spread":0.3109863235269641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}