{"id":"W2018902367","doi":"10.1155/2014/218763","title":"The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An<i>In Vitro</i>Study","year":2014,"lang":"en","type":"article","venue":"Journal of Thyroid Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tehran University of Medical Sciences and Health Services; Stem Cell Network","keywords":"Anaplastic thyroid cancer; Thyroid cancer; Cell culture; Valproic Acid; Cancer research; Medicine; Cell growth; Nestin; In vitro; Cellular differentiation; Cancer cell; Cell; Thyroid; Stem cell; Cancer; Internal medicine; Biology; Cell biology; Biochemistry; Epilepsy; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863327,0.0003246348,0.000355219,0.0002414042,0.00016234,0.0002850335,0.0002592247,0.0002284091,0.000765603],"category_scores_gemma":[0.0001028406,0.000110596,0.0005092885,0.0002058998,0.0002124467,0.0002327545,0.0001236714,0.0004319208,0.000143392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354897,"about_ca_system_score_gemma":0.0002808842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075102,"about_ca_topic_score_gemma":0.001470961,"domain_scores_codex":[0.9999032,0.00002607592,0.0000146839,0.00001335374,0.00002114756,0.00002154198],"domain_scores_gemma":[0.99994,0.00001445195,0.00001543147,0.000006819416,0.00001015825,0.00001317199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298281,0.0003290752,0.0007441381,0.0005015719,0.00004815967,0.0001788293,0.00004589979,0.0002237388,0.9822195,0.0001746459,0.0001555665,0.01408062],"study_design_scores_gemma":[0.0001114798,0.006425794,0.005081515,0.00002429096,0.0001757649,0.0003665725,0.00005233079,0.0005895403,0.981298,0.00006568874,0.005800824,0.000008164199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649898,0.03110744,0.001312828,0.0002360529,0.00007616752,0.00004645077,0.0003624012,0.00004757272,0.001821246],"genre_scores_gemma":[0.9817695,0.01530702,0.001280586,0.00008817476,0.00003771934,0.00002953124,0.0004499725,0.00001165368,0.001025772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075102,"threshold_uncertainty_score":0.00257498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03196368646026774,"score_gpt":0.3509301046955888,"score_spread":0.3189664182353211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}