{"id":"W2018923286","doi":"10.1074/jbc.m502761200","title":"Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Geranylgeranyl pyrophosphate; ABCA1; RHOA; ABCG1; Liver X receptor; Farnesyl pyrophosphate; Atorvastatin; Cholesterol; Cholesterol 7 alpha-hydroxylase; Geranylgeranylation; HMG-CoA reductase; Reverse cholesterol transport; Chemistry; Biology; Biochemistry; Endocrinology; Lipoprotein; Signal transduction; Reductase; Prenylation; Nuclear receptor; Enzyme; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003532543,0.0003539764,0.0005115175,0.000196592,0.0001456362,0.000353381,0.0002043796,0.0002684828,0.000693543],"category_scores_gemma":[0.000139936,0.0001430727,0.0004238957,0.0001617122,0.000273144,0.0001510503,0.0002378202,0.0005753101,0.0003699519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00031423,"about_ca_system_score_gemma":0.0002926594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007075971,"about_ca_topic_score_gemma":0.0014891,"domain_scores_codex":[0.9996637,0.00008787053,0.00002983088,0.00003578613,0.00007561943,0.0001072083],"domain_scores_gemma":[0.9999162,0.00001500441,0.00002189161,0.0000121038,0.00001699448,0.00001767894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003567017,0.0000475247,0.0001200445,0.0000461701,0.000008852197,0.00003858822,0.00001433109,0.00003073387,0.9975111,0.00006692802,0.00004949876,0.001709545],"study_design_scores_gemma":[0.00008548413,0.0007686943,0.002774536,0.000006509697,0.00002635962,0.0001108247,0.00001999077,0.0006055857,0.9931156,0.00005054663,0.002431658,0.000004277616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848129,0.008153456,0.003519993,0.0004186346,0.00009892377,0.00008981748,0.0002729995,0.0002235353,0.00240961],"genre_scores_gemma":[0.9910425,0.00331913,0.0024952,0.000134405,0.00003499783,0.0001294186,0.0003028433,0.00002025179,0.002521243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007075971,"threshold_uncertainty_score":0.002320111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281002259145719,"score_gpt":0.2761007513790989,"score_spread":0.2532907287876417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}