{"id":"W2018923286","doi":"10.1074/jbc.m502761200","title":"Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Geranylgeranyl pyrophosphate; ABCA1; RHOA; ABCG1; Liver X receptor; Farnesyl pyrophosphate; Atorvastatin; Cholesterol; Cholesterol 7 alpha-hydroxylase; Geranylgeranylation; HMG-CoA reductase; Reverse cholesterol transport; Chemistry; Biology; Biochemistry; Endocrinology; Lipoprotein; Signal transduction; Reductase; Prenylation; Nuclear receptor; Enzyme; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357283,0.0001605147,0.000496342,0.00003480344,0.00002983913,0.000009118558,0.00008933024,0.0002606763,0.0004462079],"category_scores_gemma":[0.0002247934,0.0001075005,0.0002581281,0.0001351353,0.0001544473,0.0001473914,0.00003597409,0.0004268206,0.000008960727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006217401,"about_ca_system_score_gemma":0.00004728901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000021948,"about_ca_topic_score_gemma":8.533987e-8,"domain_scores_codex":[0.9985648,0.0000454257,0.0007603669,0.0001671992,0.0002822193,0.0001799273],"domain_scores_gemma":[0.9988682,0.00005037977,0.0005546853,0.0001932038,0.0001814387,0.0001521369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002977292,0.0003112759,0.001386994,0.00008391469,0.00004025101,0.00001257209,0.0001024891,0.00002857636,0.9916662,0.000005659578,0.0005259433,0.005538399],"study_design_scores_gemma":[0.002252987,0.0002345947,0.04075854,0.0001860061,0.00008593843,0.0009768548,0.00005108907,0.00002531074,0.9446936,0.0001886848,0.01045042,0.00009603736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964133,0.0007769489,0.0001077243,0.001321047,0.0001059158,0.00008707993,0.00001257264,0.00001494813,0.001160471],"genre_scores_gemma":[0.9946553,0.0002416214,0.002364798,0.0004133687,0.002010975,0.00000153959,0.00002905518,0.00001021592,0.0002731372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04697265,"threshold_uncertainty_score":0.4885664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281002259145719,"score_gpt":0.2761007513790989,"score_spread":0.2532907287876417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}