{"id":"W2018937824","doi":"10.1515/bc.2006.160","title":"Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Canadian Institutes of Health Research; University of Connecticut","keywords":"Cathepsin; Proteolysis; Apolipoprotein B; Biochemistry; Chemistry; Cathepsin B; Cathepsin D; Cleavage (geology); Cathepsin H; Cathepsin L; Enzyme; Cathepsin O; Cathepsin S; Apolipoprotein E; Cathepsin A; Molecular biology; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009293952,0.000160721,0.0001597434,0.0000081055,0.00004250145,0.000007810698,0.0001788642,0.0003263568,0.00006646364],"category_scores_gemma":[0.00005581231,0.0001292816,0.0001048273,0.00006166886,0.00009705202,0.000002530161,0.00008046679,0.00007445495,0.000006524193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001328743,"about_ca_system_score_gemma":0.00002971066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008465542,"about_ca_topic_score_gemma":0.000001787127,"domain_scores_codex":[0.9990746,0.00002685605,0.0002533753,0.0003211318,0.0001064337,0.0002175496],"domain_scores_gemma":[0.9995025,0.000005922736,0.0001194671,0.0002604577,0.00005297627,0.0000586919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004832418,0.0001297802,0.0004416209,0.00001949277,0.00001000032,0.000001327373,7.123696e-7,0.000001356154,0.9962299,0.00008724292,0.002781156,0.0002491016],"study_design_scores_gemma":[0.0003365552,0.0002169836,0.00009004227,0.000009624958,0.000006300263,0.00001079481,0.000007381972,0.0000071573,0.9876997,0.0002855114,0.01116281,0.0001671792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943688,0.001145579,0.0008521512,0.00005479261,0.00003183604,0.0001324433,0.000109351,0.00002358194,0.003281461],"genre_scores_gemma":[0.9959701,0.00003221777,0.0005324619,0.00005349149,0.0003488542,0.00003301674,0.001064403,0.00001133192,0.00195418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008530223,"threshold_uncertainty_score":0.5271949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004861717379237,"score_gpt":0.2166424702606249,"score_spread":0.2065938530868325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}