{"id":"W2018937824","doi":"10.1515/bc.2006.160","title":"Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Canadian Institutes of Health Research; University of Connecticut","keywords":"Cathepsin; Proteolysis; Apolipoprotein B; Biochemistry; Chemistry; Cathepsin B; Cathepsin D; Cleavage (geology); Cathepsin H; Cathepsin L; Enzyme; Cathepsin O; Cathepsin S; Apolipoprotein E; Cathepsin A; Molecular biology; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308338,0.0003199189,0.000260645,0.0002600304,0.0001625395,0.0004500705,0.0001355256,0.0003036121,0.0004573218],"category_scores_gemma":[0.0002821409,0.0001992517,0.0003108997,0.0001313673,0.0002228254,0.000174802,0.0001593041,0.0003006244,0.00025867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004255851,"about_ca_system_score_gemma":0.0002551431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312206,"about_ca_topic_score_gemma":0.001132825,"domain_scores_codex":[0.9998693,0.00002735965,0.00001210813,0.00002364051,0.0000365981,0.00003089706],"domain_scores_gemma":[0.9999061,0.00002212058,0.00001848257,0.00001687627,0.00001856281,0.00001783073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007329,0.00001066084,0.0003271584,0.00001914626,0.000006755923,0.00009356072,0.00001178048,0.00003501604,0.9983605,0.00004753732,0.00001695718,0.0009976218],"study_design_scores_gemma":[0.00003709288,0.0002193456,0.01214126,0.000008155966,0.00002011741,0.001284591,0.00006418811,0.001263541,0.9830233,0.0001733825,0.001755314,0.000009608831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946185,0.002504387,0.001861942,0.00004788433,0.00001052722,0.00001256027,0.00007631415,0.00003115162,0.0008367039],"genre_scores_gemma":[0.9949061,0.001421359,0.001835972,0.00003174989,0.000007003973,0.00001610658,0.0002206249,0.000009906883,0.001551333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312206,"threshold_uncertainty_score":0.003087878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004861717379237,"score_gpt":0.2166424702606249,"score_spread":0.2065938530868325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}